Expression of neuroendocrine (NE) markers in primary ovarian non-NE epithelial tumors has rarely been evaluated. The aim of our study was to evaluate the expression of the most widely used NE markers in these neoplasms and to determine any prognostic significance of NE marker expression. The cohort consisted of 551 primary ovarian tumors, including serous borderline tumors, low-grade serous carcinomas, high-grade serous carcinomas (HGSC), clear cell carcinomas, endometroid carcinomas, mucinous borderline tumors, and mucinous carcinomas. Immunohistochemical analysis was performed using antibodies against INSM1, synaptophysin, chromogranin, and CD56 on tissue microarray. Positivity for INSM1, synaptophysin, chromogranin, and CD56 was most frequently observed in mucinous tumors (48.7%, 26.0%, 41.5%, and 100%, respectively). The positivity for these NE markers was mostly restricted to nonmucinous elements distributed throughout the tumor. The mucinous borderline tumor and mucinous carcinomas groups had similar proportions of positivity (mucinous borderline tumor: 53%, mucinous carcinomas: 39%). In the other tumor types, except for HGSC, there was only focal expression (5%-10%) or negativity for NE markers. HGSC showed high CD56 expression (in 26% of cases). Survival analysis was only performed for CD56 in HGSC as this was the only group with sufficient positive cases, and it showed no prognostic significance. Except for mucinous tumors, expression of NE markers in non-NE ovarian epithelial tumors is low. CD56 expression in HGSC occurs frequently but is without diagnostic or prognostic value.

中文翻译：

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卵巢原发性非神经内分泌上皮肿瘤中神经内分泌标志物的表达：551 例病例的研究。

很少评估原发性卵巢非 NE 上皮肿瘤中神经内分泌 (NE) 标志物的表达。我们研究的目的是评估这些肿瘤中最广泛使用的 NE 标记物的表达，并确定 NE 标记物表达的预后意义。该队列由 551 例原发性卵巢肿瘤组成，包括浆液性交界性肿瘤、低级别浆液性癌、高级别浆液性癌 (HGSC)、透明细胞癌、子宫内膜样癌、粘液性交界性肿瘤和粘液性癌。使用针对 INSM1、突触素、嗜铬粒蛋白和 CD56 的抗体在组织微阵列上进行免疫组织化学分析。INSM1、突触素、嗜铬粒蛋白和 CD56 的阳性最常见于粘液性肿瘤（分别为 48.7%、26.0%、41.5% 和 100%）。这些 NE 标记物的阳性主要局限于分布在整个肿瘤中的非粘液成分。粘液性交界性肿瘤和粘液性癌组的阳性比例相似（粘液性交界性肿瘤：53%，粘液性癌：39%）。在其他肿瘤类型中，除HGSC外，NE标志物仅局灶表达（5%-10%）或阴性。HGSC 显示高 CD56 表达（26% 的病例）。仅对 HGSC 中的 CD56 进行生存分析，因为这是唯一具有足够阳性病例的组，并且没有显示出预后意义。除粘液性肿瘤外，NE标志物在非NE卵巢上皮性肿瘤中表达较低。HGSC 中 CD56 表达频繁出现，但没有诊断或预后价值。