Uterine tumor resembling ovarian sex cord tumor (UTROSCT) is a rare tumor with low malignant potential that commonly occurs in middle age. Although more than 100 cases have been reported to date, myxoid morphology is not well documented. Here, we present a 75-yr-old woman with abnormal vaginal bleeding, with an 8-cm mass in the uterine corpus detected by irregular, high-intensity signaling on T2-weighted imaging. The uterine mass had a glistening mucinous appearance on gross examination. Microscopically, most of the tumor cells were floating in the myxoid stroma. The tumor cells formed clusters or nests with abundant cytoplasm, while some exhibited trabecular or rhabdoid appearances. Immunohistochemically, tumor cells were positive for pancytokeratin (AE1/AE3), α-smooth muscle actin, CD10, progesterone receptor, and some sex cord markers such as calretinin, inhibin, CD56, steroidogenic factor-1. Electron microscopy demonstrated epithelial and sex cord differentiation. This tumor was negative for JAZF1-JJAZ1 fusion gene that is frequently found in low-grade endometrial stromal sarcoma. Fusion genes related to UTROSCT, including NCOA2/3, were not detected by reverse transcription polymerase chain reaction. The present case suggests that UTROSCT should be included in the differential diagnosis of myxoid uterine tumors.

中文翻译：

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具有显着粘液样特征的类似卵巢性索肿瘤的子宫肿瘤一例。

子宫肿瘤类似卵巢性索肿瘤（UTROSCT）是一种罕见的低度恶性肿瘤，常见于中年人。尽管迄今为止已报道了 100 多例病例，但粘液样形态尚未得到充分记录。在这里，我们介绍了一名患有异常阴道出血的 75 岁女性，通过 T2 加权成像的不规则高强度信号检测到子宫体中有一个 8 厘米的肿块。肉眼检查时，子宫肿块具有闪闪发光的粘液性外观。显微镜下，大部分肿瘤细胞漂浮在粘液样基质中。肿瘤细胞形成簇状或巢状，细胞质丰富，部分呈小梁状或横纹肌样外观。免疫组织化学显示，肿瘤细胞全细胞角蛋白（AE1/AE3）、α-平滑肌肌动蛋白、CD10、孕激素受体、以及一些性索标记物，例如钙视网膜蛋白、抑制素、CD56、类固醇生成因子-1。电子显微镜显示上皮和性索分化。该肿瘤的 JAZF1-JJAZ1 融合基因呈阴性，这种基因常见于低级别子宫内膜间质肉瘤。逆转录聚合酶链反应未检测到与 UTROSCT 相关的融合基因，包括 NCOA2/3。本病例提示 UTROSCT 应纳入子宫粘液样肿瘤的鉴别诊断。逆转录聚合酶链式反应未检测到。本病例提示 UTROSCT 应纳入子宫粘液样肿瘤的鉴别诊断。逆转录聚合酶链式反应未检测到。本病例提示 UTROSCT 应纳入子宫粘液样肿瘤的鉴别诊断。