Vimentin is a stable mesenchymal immunohistochemical marker and is widely recognized as a major marker of mesenchymal tumors. The purpose of the present study was to investigate if the vimentin expression status might serve as a significant predictor of outcomes in patients with invasive breast carcinoma of no special type (IBC-NST) and to investigate, by comprehensive RNA sequencing analyses, the mechanisms involved in the heightened malignant potential of vimentin-positive IBC-NSTs. This study, conducted using the data of 855 patients with IBC-NST, clearly identified vimentin expression status as a very important independent biological parameter for accurately predicting the outcomes in patients with IBC-NST. RNA sequence analyses clearly demonstrated significant upregulation of coding RNAs known to be closely associated with cell proliferation or cellular senescence, and significant downregulation of coding RNAs known to be closely associated with transmembrane transport in vimentin-positive IBC-NSTs. We conclude that vimentin-positive IBC-NSTs show heightened malignant biological characteristics, possibly attributable to the upregulation of RNAs closely associated with proliferative activity and cellular senescence, and downregulation of RNAs closely associated with transmembrane transport in IBC-NSTs.

中文翻译：

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波形蛋白阳性非特殊类型浸润性乳腺癌：具有致命生物学特征的乳腺癌

Vimentin 是一种稳定的间叶免疫组织化学标志物，被广泛认为是间叶肿瘤的主要标志物。本研究的目的是调查波形蛋白表达状态是否可以作为非特殊类型浸润性乳腺癌 (IBC-NST) 患者预后的显着预测因子，并通过综合 RNA 测序分析来调查所涉及的机制波形蛋白阳性 IBC-NST 的恶性潜能增加。这项研究使用 855 名 IBC-NST 患者的数据进行，明确指出波形蛋白表达状态是准确预测 IBC-NST 患者预后的非常重要的独立生物学参数。RNA序列分析清楚地表明，已知与细胞增殖或细胞衰老密切相关的编码RNA显着上调，而已知与波形蛋白阳性IBC-NST中的跨膜运输密切相关的编码RNA显着下调。我们的结论是，波形蛋白阳性的 IBC-NST 显示出更高的恶性生物学特征，这可能归因于与增殖活性和细胞衰老密切相关的 RNA 的上调，以及与 IBC-NST 中跨膜运输密切相关的 RNA 的下调。