Effective adaptive immunity is rendered possible by highly organized tissue architecture and coordinated cellular crosstalk. While detailed spatiotemporal analyses of antigen presentation and adaptive immune activation in secondary lymphoid tissues have been a major focus of study, it is clear that antigen presentation in other tissues also plays a critical role in shaping the immune response. In this article, we concentrate on two opposing aspects of adaptive immunity: tolerance and antitumor immunity, to illustrate how a complex set of antigen presentation mechanisms contributes to maintaining a delicate balance between robust immunity and avoidance of autoimmune pathology. We emphasize the importance of how immune cell identity, state, and location collectively determine the nature of adaptive immune responses.

高度组织的组织结构和协调的细胞串扰使有效的适应性免疫成为可能。虽然对次级淋巴组织中抗原呈递和适应性免疫激活的详细时空分析一直是研究的主要焦点，但很明显，其他组织中的抗原呈递在形成免疫反应中也发挥着关键作用。在本文中，我们集中讨论适应性免疫的两个对立方面：耐受性和抗肿瘤免疫，以说明一组复杂的抗原呈递机制如何有助于维持强大免疫和避免自身免疫病理之间的微妙平衡。我们强调如何免疫细胞的身份、状态和位置共同决定了适应性免疫反应的性质。