Kammerer, Tobias, Anna Walzl, Thomas Müller, Philipp Groene, Giulia Roveri, Rachel Turner, Johanna Roche, Hannes Gatterer, Christoph Siebenmann, and Simon T. Schäfer. Effects of hypobaric hypoxia on coagulation in healthy subjects exposed to 3,500 m altitude. High Alt Med Biol. 24:94-103, 2023. Background: Hypoxia is discussed as a trigger for prothrombotic changes both in intensive care and high altitude medicine. This research study aimed to evaluate the effect of isolated hypobaric hypoxia (HH) on coagulation in females in a highly standardized setting. Methods: Twelve healthy female subjects were studied under HH (equivalent to 3,500 m) and normoxia (NX) during two 4-day sojourns, in a strictly controlled crossover design. Nutrition, fluid intake, hormonal status (i.e., menstrual cycle variation), and physical stress were standardized. Functional coagulation and blood lysis were measured by viscoelastometry and compared between HH and NX. In addition, plasma-based coagulation tests (PBCTs), namely prothrombin time, activated partial thromboplastin time, fibrinogen, factor VIII coagulation activity (FVIII:C), von Willebrand factor antigen (vWF:Ag), and von Willebrand factor ristocetin cofactor activity (vWF:RCo) were measured. Results: Neither for Viscoelastic Haemostatic Assays nor for PBCTs significant changes were found for HH compared with NX (all p > 0.05). Specifically, the lysis ability, as well as clotting time, clot formation, clot amplitude, and maximum clot firmness unchanged were similar between HH and NX. This also applied to all other variables. Conclusion: We demonstrate that moderate HH per se has no influence on blood coagulation in healthy females.

中文翻译：

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低压缺氧对暴露于 3,500 m 海拔的健康受试者凝血的影响。

Kammerer、托拜厄斯、安娜·瓦尔茨尔、托马斯·穆勒、菲利普·格罗内、朱利亚·罗维里、雷切尔·特纳、约翰娜·罗奇、汉内斯·加特勒、克里斯托夫·西本曼和西蒙·T·谢弗。低压缺氧对暴露于海拔 3,500 m 的健康受试者凝血的影响。高替代医学生物。24:94-103, 2023。背景：在重症监护和高原医学中，缺氧被认为是血栓前变化的触发因素。本研究旨在评估高度标准化环境中孤立性低压缺氧 (HH) 对女性凝血的影响。方法：以严格控制的交叉设计，在两次为期 4 天的停留期间，对 12 名健康女性受试者在 HH（相当于 3,500 m）和常氧（NX）下进行研究。营养、液体摄入量、荷尔蒙状态（即月经周期变化）和身体压力均已标准化。通过粘弹性测量法测量功能性凝血和血液溶解，并在 HH 和 NX 之间进行比较。此外，血浆凝血试验 (PBCT)，即凝血酶原时间、活化部分凝血活酶时间、纤维蛋白原、VIII 因子凝血活性 (FVIII:C)、冯·维勒布兰德因子抗原 (vWF:Ag) 和冯·维勒布兰德因子瑞斯托菌素辅因子活性测量了 (vWF:RCo)。结果：与 NX 相比，无论是粘弹性止血测定还是 PBCT，HH 均未发现显着变化（所有 p > 0.05）。具体而言，HH 和 NX 之间的裂解能力以及凝血时间、凝块形成、凝块幅度和最大凝块硬度没有变化相似。这也适用于所有其他变量。结论：我们证明中等 HH 本身对健康女性的凝血没有影响。