Based on a comprehensive analysis of molecular sequence data, the Sepiidae genera Acanthosepion Rochebrune, 1884; Ascarosepion Rochebrune, 1884; Aurosepina Jothinayagam, 1987; Decorisepia Iredale, 1926; Doratosepion Rochebrune, 1884; Rhombosepion Rochebrune, 1884 and Spathidosepion Rochebrune, 1884 are here re-instated and formally recognised as valid. Sepia Linnaeus, 1758 and Sepiella Gray, 1849 are retained, but Metasepia Hoyle, 1885 is placed in alternative combination with Ascarosepion. The subgenus Digitosepia Lipiński, 2020 is well supported and is herein elevated to generic status. Sepia trygonina (Rochebrune, 1884) and Sepia hieronis (Robson, 1924) are placed in new monotypic genera Erythalassa gen. nov. and Lusepia gen. nov. respectively. Hemisepius Steenstrup, 1875, also monotypic, is recognised as valid based on a unique synapomorphy: the presence of a fleshy ridge on each side of the antero-ventral mantle that bears a longitudinal row of black pores, however, H. typicus Steenstrup, 1875, was not included in our molecular analysis as tissue samples could not be obtained. Sepia tuberculata Lamarck, 1798, the type species for the nominal genus Spathidosepion, was not included for the same reason. Based on the morphological similarity between S. tuberculata and the sequenced taxa, S. papillata Quoy & Gaimard, 1832 and S. angulata Roeleveld, 1972 we tentatively assign these two taxa to Spathidosepion pending future confirmation. Where possible, each genus is diagnosed based on a combination of morphological and molecular characters.

基于对分子序列数据的综合分析，蛇科属Acanthosepion Rochebrune，1884；蛔虫Rochebrune, 1884; Aurosepina Jothinayagam, 1987; Decorisepia Iredale，1926 年；Doratosepion Rochebrune, 1884; Rhombosepion Rochebrune，1884 年和Spathidosepion Rochebrune，1884 年在这里恢复并正式承认为有效。Sepia Linnaeus, 1758 和Sepiella Gray, 1849 被保留，但Metasepia Hoyle, 1885 与Ascarosepion交替组合放置。洋地黄亚属Lipiński，2020 得到了很好的支持，并在此提升为通用状态。Sepia trygonina (Rochebrune, 1884) 和Sepia hieronis (Robson, 1924) 被归入新的单型属Erythalassa gen。十一月 和Lusepia gen。十一月 分别。Hemisepius Steenstrup，1875 年，也是单型的，基于独特的突触形态被认为是有效的：在前腹地幔的每一侧都有一个肉质脊，带有一排纵向的黑色毛孔，然而，H. typicus Steenstrup ， 1875 , 不包括在我们的分子分析中，因为无法获得组织样本。Sepia tuberculata Lamarck, 1798, 标称属的模式种出于同样的原因， Spathidosepion没有被包括在内。基于S. tuberculata和测序分类群S. papillata Quoy & Gaimard, 1832 和S. angulata Roeleveld, 1972 之间的形态学相似性，我们暂时将这两个分类群指定为Spathidosepion等待未来确认。在可能的情况下，根据形态学和分子特征的组合来诊断每个属。