Between 2% and 60% of patients with cured acromegaly may eventually develop growth hormone deficiency. In adults, growth hormone deficiency is associated with abnormal body composition, decreased exercise capacity and quality of life, dyslipidemia, insulin resistance and increased cardiovascular risk. Similar to patients with other sellar lesions, the diagnosis of growth hormone deficiency in adults with cured acromegaly generally requires stimulation testing, with the exception of patients with very low serum insulin-like growth factor I levels and multiple additional pituitary hormone deficiencies. In adults with cured acromegaly, growth hormone replacement may have beneficial effects on body adiposity, muscle endurance, serum lipids and quality of life. Growth hormone replacement is generally well-tolerated. Arthralgias, edema, carpal tunnel syndrome and hyperglycemia may occur in patients with cured acromegaly, as is true of patients with growth hormone deficiency of other etiologies. However, there is evidence of increased cardiovascular risk in some studies of growth hormone replacement in adults with cured acromegaly. More studies are needed to fully establish the beneficial effects and elucidate the risks of growth hormone replacement in adults with cured acromegaly. Until then, growth hormone replacement can be considered in these patients on a case-by-case basis.

2% 至 60% 的肢端肥大症治愈患者最终可能会出现生长激素缺乏症。在成年人中，生长激素缺乏与身体成分异常、运动能力和生活质量下降、血脂异常、胰岛素抵抗和心血管风险增加有关。与其他鞍区病变的患者类似，肢端肥大症治愈的成人生长激素缺乏症的诊断通常需要刺激试验，但血清胰岛素样生长因子 I 水平极低和多种其他垂体激素缺乏症的患者除外。对于肢端肥大症治愈的成年人，生长激素替代疗法可能对身体肥胖、肌肉耐力、血脂和生活质量产生有益影响。生长激素替代疗法通常耐受性良好。肢端肥大症治愈的患者可能会出现关节痛、水肿、腕管综合征和高血糖，其他病因导致生长激素缺乏的患者也可能出现这种情况。然而，一些对肢端肥大症治愈的成人进行生长激素替代治疗的研究表明，心血管风险增加。需要更多的研究来充分确定生长激素替代疗法对肢端肥大症治愈患者的有益效果并阐明其风险。在此之前，可以根据具体情况考虑对这些患者进行生长激素替代治疗。