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Over 20% Carbon-13 Polarization of Perdeuterated Pyruvate Using Reversible Exchange with Parahydrogen and Spin-Lock Induced Crossing at 50 μT
The Journal of Physical Chemistry Letters ( IF 4.8 ) Pub Date : 2023-06-02 , DOI: 10.1021/acs.jpclett.3c00707 Andreas B Schmidt 1, 2, 3 , James Eills 4 , Laurynas Dagys 5 , Martin Gierse 5 , Michael Keim 5 , Sebastian Lucas 5 , Michael Bock 1 , Ilai Schwartz 5 , Maxim Zaitsev 1 , Eduard Y Chekmenev 3 , Stephan Knecht 5
The Journal of Physical Chemistry Letters ( IF 4.8 ) Pub Date : 2023-06-02 , DOI: 10.1021/acs.jpclett.3c00707 Andreas B Schmidt 1, 2, 3 , James Eills 4 , Laurynas Dagys 5 , Martin Gierse 5 , Michael Keim 5 , Sebastian Lucas 5 , Michael Bock 1 , Ilai Schwartz 5 , Maxim Zaitsev 1 , Eduard Y Chekmenev 3 , Stephan Knecht 5
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Carbon-13 hyperpolarized pyruvate is about to become the next-generation contrast agent for molecular magnetic resonance imaging of cancer and other diseases. Here, efficient and rapid pyruvate hyperpolarization is achieved via signal amplification by reversible exchange (SABRE) with parahydrogen through synergistic use of substrate deuteration, alternating, and static microtesla magnetic fields. Up to 22 and 6% long-lasting 13C polarization (T1 = 3.7 ± 0.25 and 1.7 ± 0.1 min) is demonstrated for the C1 and C2 nuclear sites, respectively. The remarkable polarization levels become possible as a result of favorable relaxation dynamics at the microtesla fields. The ultralong polarization lifetimes will be conducive to yielding high polarization after purification, quality assurance, and injection of the hyperpolarized molecular imaging probes. These results pave the way to future in vivo translation of carbon-13 hyperpolarized molecular imaging probes prepared by this approach.
中文翻译：
在 50 μT 下使用与仲氢的可逆交换和自旋锁诱导交叉对全氘丙酮酸盐进行超过 20% 的碳 13 极化
Carbon-13超极化丙酮酸盐即将成为癌症和其他疾病分子磁共振成像的下一代造影剂。在这里，通过协同使用底物氘化、交变和静态微特斯拉磁场，通过可逆交换 (SABRE) 与仲氢进行信号放大，实现高效快速的丙酮酸超极化。高达 22 和 6% 的持久13 C 极化 ( T 1= 3.7 ± 0.25 和 1.7 ± 0.1 分钟）分别针对 C1 和 C2 核站点进行了演示。由于微特斯拉场有利的弛豫动力学，显着的极化水平成为可能。超长极化寿命将有助于在超极化分子成像探针的纯化、质量保证和注入后产生高极化。这些结果为未来通过这种方法制备的碳 13 超极化分子成像探针的体内翻译铺平了道路。
更新日期：2023-06-02
中文翻译：
在 50 μT 下使用与仲氢的可逆交换和自旋锁诱导交叉对全氘丙酮酸盐进行超过 20% 的碳 13 极化
Carbon-13超极化丙酮酸盐即将成为癌症和其他疾病分子磁共振成像的下一代造影剂。在这里，通过协同使用底物氘化、交变和静态微特斯拉磁场，通过可逆交换 (SABRE) 与仲氢进行信号放大，实现高效快速的丙酮酸超极化。高达 22 和 6% 的持久13 C 极化 ( T 1= 3.7 ± 0.25 和 1.7 ± 0.1 分钟）分别针对 C1 和 C2 核站点进行了演示。由于微特斯拉场有利的弛豫动力学，显着的极化水平成为可能。超长极化寿命将有助于在超极化分子成像探针的纯化、质量保证和注入后产生高极化。这些结果为未来通过这种方法制备的碳 13 超极化分子成像探针的体内翻译铺平了道路。
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