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Photocatalytic Benzylic C–H Oxidation/Cyclization of Enaminones to the Synthesis of Polysubstituted Oxazoles
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2023-06-01 , DOI: 10.1021/acs.joc.3c00269
Mingrui Li 1 , Zhiqin He 2 , Wei Zhao 2 , Yang Yu 3 , Fei Huang 1 , Jonathan B Baell 1
Affiliation  

Photocatalytic benzylic C–H oxidation/cyclization of enaminones was efficiently achieved to afford oxazole derivatives under mild conditions. The oxygen in the oxazole ring originated from green oxidant molecular oxygen. The synthetic protocol features broad substrate scopes and good functional group tolerance. The combined experimental and theoretical studies reveal that in suit benzylic C–H oxidation/cyclization is involved in the reaction transformations.

中文翻译:

烯胺酮光催化苄基C-H氧化/环化合成多取代恶唑

在温和条件下,有效地实现了烯胺酮的光催化苄基C-H氧化/环化,得到恶唑衍生物。恶唑环中的氧来源于绿色氧化剂分子氧。该合成方案具有广泛的底物范围和良好的官能团耐受性。综合实验和理论研究表明,适当的苄基 C-H 氧化/环化参与了反应转化。
更新日期:2023-06-01
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