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Electrochemical Oxidative C–H Amination through a Ritter-Type Reaction
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2023-06-01 , DOI: 10.1021/acs.joc.3c00609
Yiwen Xu 1 , Qiang Li 1 , Runyou Ye 1 , Buyi Xu 2 , Xiangge Zhou 1
Affiliation  

A straightforward strategy for direct benzylic C–H bond amination via an electrochemical Ritter-type reaction is developed. The reaction demonstrates simpler and milder reaction conditions over the existing methods without extra mediator. Moderate to excellent yields up to 94% of the desired amide products were obtained with a broad substrate scope. The removal of the Ac group by a simple step can afford NH-free benzylic amines, providing a suitable approach for the late-stage functionalization of bioactive molecules.

中文翻译:

通过 Ritter 型反应进行电化学氧化 C–H 胺化

开发了一种通过电化学 Ritter 型反应直接进行苄基 C-H 键胺化的简单策略。该反应比现有方法表现出更简单、更温和的反应条件,无需额外的介体。在广泛的底物范围内获得了中等至优异的收率,高达 94% 的所需酰胺产物。通过简单的步骤去除Ac基团可以得到不含NH的苄胺,为生物活性分子的后期功能化提供了合适的方法。
更新日期:2023-06-01
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