Portable Handheld “SkinPen” Loaded with Biomaterial Ink for In Situ Wound Healing,ACS Applied Materials & Interfaces

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Portable Handheld “SkinPen” Loaded with Biomaterial Ink for In Situ Wound Healing
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2023-06-01 , DOI: 10.1021/acsami.3c02825
Fuyuan Zhou _{1,

2,

3} , Liangjing Xin _{1,

2,

3} , Shuya Wang _{4,

5} , Kaiwen Chen _{4,

5} , Dize Li _{1,

2,

3} , Si Wang _{1,

2,

3} , Yuanding Huang _{1,

2,

3} , Chuanhang Xu _{1,

2,

3} , Mengjiao Zhou _{1,

2,

3} , Wenjie Zhong _{1,

2,

3} , Huanan Wang _{4,

5} , Tao Chen _{1,

2,

3} , Jinlin Song _{1,

2,

3}

Affiliation

In situ bioprinting has emerged as an attractive tool for directly depositing therapy ink at the defective area to adapt to the irregular wound shape. However, traditional bioprinting exhibits an obvious limitation in terms of an unsatisfactory bioadhesive effect. Here, a portable handheld bioprinter loaded with biomaterial ink is designed and named “SkinPen”. Gelatin methacrylate (GelMA) and Cu-containing bioactive glass nanoparticles (Cu-BGn) serve as the main components to form the hydrogel ink, which displays excellent biocompatibility and antibacterial and angiogenic properties. More importantly, by introducing ultrasound and ultraviolet in a sequential programmed manner, the SkinPen achieves in situ instant gelation and amplified (more than threefold) bioadhesive shear strength. It is suggested that ultrasound-induced cavitation and the resulting topological entanglement contribute to the enhanced bioadhesive performance together. Combining the ultrasound-enhanced bioadhesion with the curative role of the hydrogel, the SkinPen shows a satisfactory wound-healing effect in diabetic rats. Given the detachable property of the SkinPen, the whole device can be put in a first-aid kit. Therefore, the application scenarios can be expanded to many kinds of accidents. Overall, this work presents a portable handheld SkinPen that might provide a facile but effective approach for clinical wound management.

中文翻译：

装有生物材料墨水的便携式手持“SkinPen”用于原位伤口愈合

原位生物打印已成为一种有吸引力的工具，可在缺陷区域直接沉积治疗墨水以适应不规则的伤口形状。然而，传统的生物打印在不令人满意的生物粘附效果方面表现出明显的局限性。在这里，设计了一种装有生物材料墨水的便携式手持式生物打印机，并将其命名为“SkinPen”。甲基丙烯酸明胶（GelMA）和含铜生物活性玻璃纳米粒子（Cu-BGn）作为形成水凝胶墨水的主要成分，具有优异的生物相容性和抗菌和血管生成特性。更重要的是，通过以顺序编程的方式引入超声波和紫外线，SkinPen 实现了原位即时凝胶化和放大（超过三倍）的生物粘附剪切强度。这表明超声诱导的空化和由此产生的拓扑纠缠共同有助于增强生物粘附性能。结合超声增强的生物粘附和水凝胶的治疗作用，SkinPen 在糖尿病大鼠中显示出令人满意的伤口愈合效果。鉴于SkinPen的可拆卸特性，整个设备可以放入急救箱中。因此，应用场景可以扩展到多种事故。总的来说，这项工作提出了一种便携式手持式 SkinPen，它可能为临床伤口管理提供一种简单而有效的方法。SkinPen在糖尿病大鼠身上显示出令人满意的伤口愈合效果。鉴于SkinPen的可拆卸特性，整个设备可以放入急救箱中。因此，应用场景可以扩展到多种事故。总的来说，这项工作提出了一种便携式手持式 SkinPen，它可能为临床伤口管理提供一种简单而有效的方法。SkinPen在糖尿病大鼠身上显示出令人满意的伤口愈合效果。鉴于SkinPen的可拆卸特性，整个设备可以放入急救箱中。因此，应用场景可以扩展到多种事故。总的来说，这项工作提出了一种便携式手持式 SkinPen，它可能为临床伤口管理提供一种简单而有效的方法。

更新日期：2023-06-01

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