Extinction memory retrieval is influenced by spatial contextual information that determines responding to conditioned stimuli (CS). However, it is poorly understood whether contextual representations are imbued with emotional values to support memory selection. Here, we performed activity-dependent engram tagging and in vivo single-unit electrophysiological recordings from the ventral hippocampus (vH) while optogenetically manipulating basolateral amygdala (BLA) inputs during the formation of cued fear extinction memory. During fear extinction when CS acquire safety properties, we found that CS-related activity in the vH reactivated during sleep consolidation and was strengthened upon memory retrieval. Moreover, fear extinction memory was facilitated when the extinction context exhibited precise coding of its affective zones. Last, these activity patterns along with the retrieval of the fear extinction memory were dependent on glutamatergic transmission from the BLA during extinction learning. Thus, fear extinction memory relies on the formation of contextual and stimulus safety representations in the vH instructed by the BLA.

中文翻译：

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恐惧消退依赖于由杏仁核形成的腹侧海马安全代码

消退记忆检索受到空间上下文信息的影响，空间上下文信息决定对条件刺激（CS）的反应。然而，人们对上下文表征是否充满情感价值以支持记忆选择还知之甚少。在这里，我们对腹侧海马（vH）进行了活动依赖性印迹标记和体内单单元电生理记录，同时在提示恐惧消退记忆的形成过程中通过光遗传学操作基底外侧杏仁核（BLA）输入。在恐惧消退期间，当 CS 获得安全特性时，我们发现 vH 中与 CS 相关的活动在睡眠巩固期间重新激活，并在记忆检索时得到加强。此外，当消退情境表现出其情感区的精确编码时，恐惧消退记忆就会得到促进。最后，这些活动模式以及恐惧消退记忆的恢复依赖于消退学习过程中 BLA 的谷氨酸能传递。因此，恐惧消退记忆依赖于 BLA 指示的 vH 中情境和刺激安全表征的形成。