Continuous glucose monitoring (CGM) allows patients with diabetes to manage critical disease effectively and autonomously and prevent exacerbation. A painless, wireless, compact, and minimally invasive device that can provide CGM is essential for monitoring the health conditions of freely moving patients with diabetes. Here, we propose a glucose-responsive fluorescence-based highly sensitive biodegradable microneedle CGM system. These ultrathin and ultralight microneedle sensor arrays continuously and precisely monitored glucose concentration in the interstitial fluid with minimally invasive, pain-free, wound-free, and skin inflammation–free outcomes at various locations and thicknesses of the skin. Bioresorbability in the body without a need for device removal after use was a key characteristic of the microneedle glucose sensor. We demonstrated the potential long-term use of the bioresorbable device by applying the tether-free CGM system, thus confirming the successful detection of glucose levels based on changes in fluorescence intensity. In addition, this microneedle glucose sensor with a user-friendly designed home diagnosis system using mobile applications and portable accessories offers an advance in CGM and its applicability to other bioresorbable, wearable, and implantable monitoring device technology.

中文翻译：

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基于荧光的可生物降解微针传感器阵列，用于通过智能手机应用程序进行无绳连续血糖监测

连续血糖监测 (CGM) 使糖尿病患者能够有效、自主地管理危重疾病并防止病情恶化。一种可提供 CGM 的无痛、无线、紧凑、微创设备对于监测自由活动的糖尿病患者的健康状况至关重要。在这里，我们提出了一种基于葡萄糖响应荧光的高灵敏度可生物降解微针 CGM 系统。这些超薄、超轻的微针传感器阵列连续、精确地监测组织液中的葡萄糖浓度，在皮肤的不同位置和厚度处实现微创、无痛、无伤口和无皮肤炎症的结果。微针葡萄糖传感器的一个关键特性是在体内具有生物可吸收性，使用后无需移除装置。我们通过应用无绳 CGM 系统展示了生物可吸收装置的长期使用潜力，从而证实了基于荧光强度变化的葡萄糖水平的成功检测。此外，这种微针葡萄糖传感器具有用户友好型设计的家庭诊断系统，使用移动应用程序和便携式配件，在 CGM 及其对其他生物可吸收、可穿戴和植入式监测设备技术的适用性方面取得了进步。