当前位置: X-MOL 学术Dalton Trans. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Synthesis, characterization, photophysical and electrochemical properties, and biomolecular interaction of 2,2′-biquinoline based phototoxic Ru(II)/Ir(II) complexes
Dalton Transactions ( IF 3.5 ) Pub Date : 2023-06-01 , DOI: 10.1039/d3dt01348k
Utpal Das 1 , Priyankar Paira 1
Affiliation  

The phototoxic nature of drugs has been seen to convey immense importance in photo activated chemotherapy (PACT) for the selective treatment of disease. Rationally, in order to eradicate the vehemence of cancer in a living body, the design of phototoxic molecules has been of growing interest in research to establish a selective strategy for cancer therapy. Therefore, the present work portrays the synthesis of a phototoxic anticancer agent by incorporating ruthenium(II) and iridium(III) metals into a biologically active 2,2′-biquinoline moiety, BQ. The complexes, RuBQ and IrBQ, have been revealed as effective anticancer agents with remarkable toxicity in the presence of light compared to the dark towards HeLa and MCF-7 cancer cell lines due to the production of a profuse amount of singlet oxygen (1O2) upon irradiation by visible light (400–700 nm). Complex IrBQ exhibited the best toxicity (IC50 = 8.75 μM in MCF-7 and 7.23 μM in HeLa) in comparison to the RuBQ complex under visible light. RuBQ and IrBQ displayed considerable quantum yields (Φf) along with a good lipophilic property, indicating the cellular imaging capability of both complexes upon significant accumulation in cancer cells. Also, the complexes have shown significant binding propensity with biomolecules, viz. deoxyribonucleic acid (DNA) as well as serum albumin (BSA, HSA).

中文翻译:

2,2'-联喹啉基光毒Ru(II)/Ir(II)配合物的合成、表征、光物理和电化学性质以及生物分子相互作用

药物的光毒性性质在光激活化疗 (PACT) 中对于疾病的选择性治疗具有极其重要的意义。从理性上讲,为了消除活体中癌症的严重性,光毒性分子的设计在建立癌症治疗选择性策略的研究中越来越引起人们的兴趣。因此,本工作描述了通过将钌( II )和铱( III )金属掺入生物活性2,2'-联喹啉部分BQ来合成光毒性抗癌剂。RuBQIrBQ复合物已被证明是有效的抗癌剂,与黑暗相比,由于产生大量单线态氧 ( 1 O 2)在可见光(400–700 nm)照射下。与可见光下的RuBQ复合物相比,复合物IrBQ表现出最佳的毒性(MCF-7 中的 IC 50 = 8.75 μM,HeLa 中的 IC 50 = 7.23 μM)。RuBQIrBQ显示出相当大的量子产率 ( Φ f ) 以及良好的亲脂性,表明两种复合物在癌细胞中显着积累后具有细胞成像能力。此外,该复合物显示出与生物分子的显着结合倾向,。脱氧核糖核酸 (DNA) 以及血清白蛋白 (BSA、HSA)。
更新日期:2023-06-01
down
wechat
bug