A Directly Moldable, Highly Compact, and Easy-for-Integration 3D Micromixer with Extraordinary Mixing Performance,Analytical Chemistry

当前位置： X-MOL 学术 › Anal. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

A Directly Moldable, Highly Compact, and Easy-for-Integration 3D Micromixer with Extraordinary Mixing Performance
Analytical Chemistry ( IF 6.7 ) Pub Date : 2023-06-01 , DOI: 10.1021/acs.analchem.3c00335
Zhenghao Wang ₁ , Xingyang Yan ₁ , Qizhi Zhou _{1,

2} , Qiaoyi Wang ₁ , Dongliang Zhao ₂ , Hongkai Wu _{1,

3}

Affiliation

Micromixers are a critical component in microfluidics. However, most 2D passive micromixers produce optimal mixing at a high flow rate range and 3D micromixers require mm-scale channels or a complex assembly that is unsuitable for microfluidic applications. Here, we reported a 3D PDMS micromixer based on the splitting–stretching–recombination (SSR) of streams to facilitate molecular diffusion, which can effectively and rapidly mix solutions with low Reynolds numbers (0.01–10). The fabrication of our micromixer is convenient with only two steps─two-photon polymerization (2PP) 3D printing and soft lithography, with high resolution, reproducibility, and ease for integration. We investigated the mixing performance of the micromixer by CFD simulations and experimental studies under a confocal microscope; the results confirmed its better performance and higher chip miniaturization than others. It can achieve a mixing efficiency above 0.90 (which is generally regarded as complete mixing) for low-Re solutions (flow rates ≤60 μL/min) with a mixing volume smaller than 20 nL. The time for complete mixing is in the range of milliseconds (e.g., 21 ms for Re = 10, 194 ms for Re = 0.88). The device shows negligible degradation in mixing performance for highly viscous solutions (∼50 times more viscous than water), macromolecule solutions, and colloidal solutions of nanoparticles.

中文翻译：

具有非凡混合性能的可直接成型、高度紧凑且易于集成的 3D 微混合器

微混合器是微流体的重要组成部分。然而，大多数 2D 被动微混合器在高流速范围内产生最佳混合，而 3D 微混合器需要毫米级通道或不适合微流体应用的复杂组件。在这里，我们报道了一种基于流的分裂-拉伸-重组 (SSR) 以促进分子扩散的 3D PDMS 微混合器，它可以有效快速地混合具有低雷诺数 (0.01-10) 的溶液。我们的微混合器的制造非常方便，只需两个步骤─双光子聚合 (2PP) 3D 打印和软光刻，具有高分辨率、可重复性和易于集成的特点。我们通过 CFD 模拟和共聚焦显微镜下的实验研究研究了微混合器的混合性能；结果证实了它比其他的更好的性能和更高的芯片小型化。可达到0.90以上的混合效率（一般认为混合完全）混合体积小于 20 nL 的Re溶液（流速≤60 μL/min）。完全混合的时间在毫秒范围内（例如，Re = 10 为 21 ms， Re = 0.88为 194 ms ）。对于高粘度溶液（比水粘稠约 50 倍）、大分子溶液和纳米粒子的胶体溶液，该装置的混合性能下降可忽略不计。

更新日期：2023-06-01

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11