Associated with high-risk human papillomavirus infection, invasive stratified mucin-producing carcinoma is a recently characterized adenocarcinoma of the cervix. It often occurs in association with adjacent stratified mucin-producing intraepithelial lesion. Differentiated vulvar intraepithelial neoplasia and related invasive squamous cell carcinoma often arise in background vulvar lichen sclerosus with TP53 mutation as the underlying molecular signature. We present a unique case of vulvar invasive stratified mucin-producing carcinoma-like component coexisting with invasive squamous cell carcinoma in a 64-year-old woman. Both neoplastic components were proven TP53 -driven processes arising in the background of differentiated vulvar intraepithelial neoplasia and lichen sclerosus. The invasive stratified mucin-producing carcinoma-like component behaved aggressively in this case, evidenced by the presence of lymphovascular invasion and inguinal lymph node metastasis.

中文翻译：

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TP53 突变驱动的分层产生粘蛋白的癌与外阴鳞状细胞癌共存：案例研究。

与高危人乳头瘤病毒感染相关，侵袭性复层粘蛋白产生癌是最近表征的宫颈腺癌。它通常与邻近的分层产生粘蛋白的上皮内病变相关。分化的外阴上皮内瘤变和相关的侵袭性鳞状细胞癌通常出现在外阴硬化性苔藓背景中，以 TP53 突变作为潜在的分子特征。我们介绍了一名 64 岁女性的外阴浸润性复层粘蛋白癌样成分与浸润性鳞状细胞癌共存的独特病例。这两种肿瘤成分均被证明是 TP53 驱动的过程，出现在分化的外阴上皮内瘤变和硬化性苔藓的背景下。在该病例中，侵袭性复层产生粘蛋白的癌样成分表现出侵袭性，淋巴血管侵犯和腹股沟淋巴结转移的存在证明了这一点。