Although new antibiofilm agents have been developed to prevent and eliminate pathogenic biofilms, their widespread clinical use is hindered by poor biocompatibility and bioavailability, unspecific interactions and insufficient local concentrations. The development of innovative drug delivery strategies can facilitate penetration of antimicrobials through biofilms, promote drug dispersal and synergistic bactericidal effects, and provide novel paradigms for clinical application. In this Review, we discuss the potential benefits of such emerging techniques for improving the clinical efficacy of antibiofilm agents, as well as highlighting the existing limitations and future prospects for these therapies in the clinic.

尽管已经开发出新的抗生物膜剂来预防和消除致病性生物膜，但其广泛的临床应用受到生物相容性和生物利用度差、非特异性相互作用和局部浓度不足的阻碍。创新药物递送策略的发展可以促进抗菌药物通过生物膜的渗透，促进药物分散和协同杀菌作用，并为临床应用提供新的范例。在这篇综述中，我们讨论了此类新兴技术在提高抗生物膜药物临床疗效方面的潜在益处，并强调了这些疗法在临床中的现有局限性和未来前景。