A coding variant in the microsomal triglyceride transfer protein reduces both hepatic steatosis and plasma lipids,Alimentary Pharmacology & Therapeutics

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A coding variant in the microsomal triglyceride transfer protein reduces both hepatic steatosis and plasma lipids
Alimentary Pharmacology & Therapeutics ( IF 7.6 ) Pub Date : 2023-05-29 , DOI: 10.1111/apt.17566
Carolin V Schneider _{1,

2,

3} , Leonida Hehl ₁ , Kate T Creasy ₄ , Cecilia Vitali ₅ , Mara S Vell ₁ , Marijana Vujkovic ₂ , Joseph Park ₂ , Eleonora Scorletti _{2,

3} , Katharina S Seeling ₁ , Miriam D Rendel ₁ , Donna M Conlon ₅ , Helen Huang ₂ , Inuk Zandvakili _{2,

6} , Swati Valmiki ₇ , ₈ , Kai Markus Schneider _{1,

9} , M Mahmood Hussain ₇ , Daniel J Rader ₅

Affiliation

Department of Medicine III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany.
Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
The Institute for Translational Medicine and Therapeutics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Department of Biobehavioral Health Sciences, School of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Department of Medicine, Division of Translational Medicine and Human Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Department of Medicine, Division of Gastroenterology and Hepatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Department of Foundations of Medicine, NYU Long Island School of Medicine, Mineola, New York, USA.
Regeneron Genetics Center, Tarrytown, New York, USA.
Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Genetic inactivation and pharmacologic inhibition of the microsomal triglyceride transfer protein (MTP; gene name MTTP) inhibits hepatic secretion of VLDL, thereby reducing serum lipids and apoB at the expense of increasing hepatic steatosis.

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