Fexofenadine hydrochloride is an antihistamine drug which is used in the treatment of allergy symptoms, like urticaria and hay fever. In this research, the solubility of fexofenadine hydrochloride was measured in supercritical carbon dioxide (SC-CO₂) at different pressures (120–270 bar) and temperatures (308.2–338.2 K), for the first time. The solubility data were in the range of 0.073 < y × 10⁴ < 0.854. The experimental data on the solubility of fexofenadine hydrochloride were correlated by two approaches: (1) three cubic equations of state (CEoSs) with two mixing rules, and (2) nine density-based correlations with 3–6 adjustable parameters. Among CEoS, Peng-Robinson EoS with Kwak-Mansoori mixing rule, showed more accuracy, especially at higher pressures with an average absolute relative deviation percent (AARD%) of 5.48. Moreover, Garlapati and Madras (model I) with AARD% of 5.65 showed more accurate correlation compared to density-based models. Finally, total, vaporization, and solvation enthalpies of the fexofenadine hydrochloride-CO₂ system were calculated to be 39.5759, 52.4635, and − 12.8876 kJ.mol⁻¹, respectively.

Fexofenadine hydrochloride 是一种抗组胺药，用于治疗过敏症状，如荨麻疹和花粉症。在本研究中，首次在超临界二氧化碳 (SC-CO _{2 ) 中，在不同压力 (120–270 bar) 和温度 (308.2–338.2 K) 下测量了盐酸非索非那定的溶解度。}^{溶解度数据在 0.073 < y × 10 4}范围内< 0.854。盐酸非索非那定溶解度的实验数据通过两种方法相互关联：(1) 具有两个混合规则的三个立方状态方程 (CEoS)，以及 (2) 具有 3-6 个可调参数的九个基于密度的相关性。在 CEOs 中，采用 Kwak-Mansoori 混合规则的 Peng-Robinson EoS 显示出更高的准确性，尤其是在较高压力下，平均绝对相对偏差百分比 (AARD%) 为 5.48。此外，与基于密度的模型相比，AARD% 为 5.65 的 Garlapati 和 Madras（模型 I）显示出更准确的相关性。最后，计算出非索非那定盐酸盐-CO ₂系统的总焓、蒸发焓和溶剂化焓分别为 39.5759、52.4635 和 - 12.8876 kJ.mol ^-1。