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Wearable Electrochemical Glucose Sensors in Diabetes Management: A Comprehensive Review
Chemical Reviews ( IF 51.4 ) Pub Date : 2023-05-30 , DOI: 10.1021/acs.chemrev.3c00078
Tamoghna Saha 1 , Rafael Del Caño 1, 2 , Kuldeep Mahato 1 , Ernesto De la Paz 1 , Chuanrui Chen 1 , Shichao Ding 1 , Lu Yin 1 , Joseph Wang 1
Affiliation  

With the rising diabetic population, the demand for glucose sensing devices has also been on an increasing trend. Accordingly, the field of glucose biosensors for diabetes management has witnessed tremendous scientific and technological advancements since the introduction of the first enzymatic glucose biosensor in the 1960s. Among these, electrochemical biosensors hold considerable potential for tracking dynamic glucose profiles in real time. The recent evolution of wearable devices has opened opportunities to use alternative body fluids in a pain-free, noninvasive or minimally invasive manner. This review aims to present a comprehensive report about the status and promise of wearable electrochemical sensors for on-body glucose monitoring. We start by highlighting the importance of diabetes management and how sensors can contribute toward its effective monitoring. We then discuss the electrochemical glucose sensing mechanisms, evolution of such glucose sensors over time, different versions of wearable glucose biosensors targeting various biofluids, and multiplexed wearable sensors toward optimal diabetes management. Finally, we focus on the commercial aspects of wearable glucose biosensors, starting with existing continuous glucose monitors, followed by other emerging sensing technologies, and concluding with highlighting the key prospects toward personalized diabetes management in connection to an autonomous closed-loop artificial pancreas.

中文翻译:

可穿戴电化学血糖传感器在糖尿病管理中的应用:全面综述

随着糖尿病人口的不断增加,对葡萄糖传感设备的需求也呈增长趋势。因此,自 20 世纪 60 年代推出第一个酶促葡萄糖生物传感器以来,用于糖尿病管理的葡萄糖生物传感器领域见证了巨大的科学和技术进步。其中,电化学生物传感器在实时跟踪动态葡萄糖分布方面具有相当大的潜力。可穿戴设备的最新发展为以无痛、无创或微创方式使用替代体液提供了机会。本综述旨在提供一份关于用于体内血糖监测的可穿戴电化学传感器的现状和前景的综合报告。我们首先强调糖尿病管理的重要性以及传感器如何有助于其有效监测。然后,我们讨论电化学葡萄糖传感机制、此类葡萄糖传感器随时间的演变、针对各种生物流体的不同版本的可穿戴葡萄糖生物传感器,以及实现最佳糖尿病管理的多路可穿戴传感器。最后,我们重点关注可穿戴葡萄糖生物传感器的商业方面,从现有的连续血糖监测仪开始,然后是其他新兴传感技术,最后强调与自主闭环人工胰腺相关的个性化糖尿病管理的关键前景。针对各种生物流体的不同版本的可穿戴葡萄糖生物传感器,以及实现最佳糖尿病管理的多路可穿戴传感器。最后,我们重点关注可穿戴葡萄糖生物传感器的商业方面,从现有的连续血糖监测仪开始,然后是其他新兴传感技术,最后强调与自主闭环人工胰腺相关的个性化糖尿病管理的关键前景。针对各种生物流体的不同版本的可穿戴葡萄糖生物传感器,以及实现最佳糖尿病管理的多路可穿戴传感器。最后,我们重点关注可穿戴葡萄糖生物传感器的商业方面,从现有的连续血糖监测仪开始,然后是其他新兴传感技术,最后强调与自主闭环人工胰腺相关的个性化糖尿病管理的关键前景。
更新日期:2023-05-30
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