As the typical toxic and hazardous gases, volatile organic compounds (VOCs) and hydrogen sulfide (H₂S) pose a threat to the environment and human health. The demand for real-time detection of VOCs and H₂S gases is growing in many application to protect human health and air quality. Therefore, it is essential to develop advance sensing materials for the construction of effective and reliable gas sensors. Herein, bimetallic spinel ferrites with different metal ions (MFe₂O₄, M = Co, Ni, Cu and Zn) were designed by using metal-organic frameworks as templates. The evaluation of cation substitution on crystal structures (inverse/normal spinel structure) and electrical properties (n/p type and band gap) is systematically discussed. The results indicate that p-type NiFe₂O₄ and n-type CuFe₂O₄ nanocubes with inverse spinel structure exhibit high response and great selectivity towards acetone (C₃H₆O) and H₂S, respectively. Moreover, the two sensors also display the detection limits as low as 1 ppm (C₃H₆O) and 0.5 ppm (H₂S), which are far below the threshold values of 750 ppm to acetone and 10 ppm to H₂S for 8 h exposure set by American Conference of Governmental Industrial Hygienists (ACGIH). The finding provides new possibilities for the design of high-performance chemical sensors, which display tremendous potential for practical applications.

_{挥发性有机化合物(VOCs)和硫化氢(H 2 S)}作为典型的有毒有害气体，对环境和人类健康构成威胁。为了保护人类健康和空气质量，许多应用对实时检测 VOC 和 H _{2 S 气体的需求不断增长。}因此，有必要开发先进的传感材料来构建有效、可靠的气体传感器。在此，具有不同金属离子的双金属尖晶石铁氧体（MFe ₂ O ₄，M = Co，Ni，Cu和Zn）是通过使用金属有机骨架作为模板设计的。系统地讨论了阳离子取代对晶体结构（反/正尖晶石结构）和电性能（n/p型和带隙）的评估。结果表明，具有反尖晶石结构的p型NiFe ₂ O ₄和n型CuFe ₂ O _{4纳米立方体分别对丙酮(C 3} H ₆ O)和H ₂ S表现出高响应性和高选择性。此外，这两个传感器还显示低至 1 ppm (C ₃ H ₆ O) 和 0.5 ppm (H ₂S)，远低于美国政府工业卫生学家会议 (ACGIH) 规定的暴露 8 小时丙酮浓度为 750 ppm 和 H ₂ S浓度为 10 ppm 的阈值。这一发现为高性能化学传感器的设计提供了新的可能性，在实际应用中显示出巨大的潜力。