Osteoarthritis (OA) is one of the leading causes of chronic disability in the elderly. Effective clinical interventions for OA are still lacking, and new therapeutic measures are urgently needed. The emerging near-infrared light (NIR) sensitive nanozymes are attractive for their great potential and appeal in treating OA by repairing mitochondrial function and improving impaired autophagic flux. In this study, a NIR-sensitive tea polyphenol-modified zirconium-based porphyrin metal–organic framework (TP-Au@PCN) was introduced as a multifunctional nanoplatform for the treatment of OA. TEM and EDS mapping revealed that gold nanoclusters were uniformly distributed on the surface of the spherical particles. Electron spin resonance (ESR) analysis revealed that nanozymes could alleviate different types of oxidative stress. Molecular biology indicated that TP-Au@PCN reduced chondrocyte apoptosis and increased chondrocyte metabolism by 80.7%. An increase in chondrocyte-expressed type II collagen and proteoglycan content ensues. Injection of TP-Au@PCN effectively raised the joint temperature to 46.9 °C and controlled drug delivery under NIR excitation. Section staining revealed that eight weeks of intervention decreased the OARSI score in OA rats by approximately 67.0%. Transmission electron microscopy confirmed a significant improvement in intracellular mitochondrial morphology. The present study provides evidence that modifiable multifunctional nanozymes effectively repair cartilage-damaged mitochondria and promote cartilage regeneration, representing an appealing therapeutic strategy for OA.

骨关节炎（OA）是老年人慢性残疾的主要原因之一。目前仍缺乏有效的骨关节炎临床干预措施，迫切需要新的治疗措施。新兴的近红外光 (NIR) 敏感纳米酶因其通过修复线粒体功能和改善受损自噬通量治疗 OA 的巨大潜力和吸引力而具有吸引力。在这项研究中，引入了一种 NIR 敏感的茶多酚修饰的锆基卟啉金属有机骨架 (TP-Au@PCN) 作为治疗 OA 的多功能纳米平台。TEM 和 EDS 映射显示金纳米团簇均匀分布在球形颗粒的表面。电子自旋共振 (ESR) 分析表明，纳米酶可以缓解不同类型的氧化应激。分子生物学表明，TP-Au@PCN 减少了软骨细胞凋亡，增加了 80.7% 的软骨细胞代谢。随之而来的是软骨细胞表达的 II 型胶原蛋白和蛋白多糖含量的增加。注射 TP-Au@PCN 有效地将关节温度提高到 46.9 °C，并在 NIR 激发下控制药物输送。切片染色显示，八周的干预使 OA 大鼠的 OARSI 评分降低了约 67.0%。透射电子显微镜证实了细胞内线粒体形态的显着改善。本研究提供的证据表明，可修饰的多功能纳米酶可有效修复软骨受损的线粒体并促进软骨再生，代表了一种有吸引力的 OA 治疗策略。