Context and objectives

Gestational diabetes mellitus (GDM) is the most common metabolic disorder in pregnancy, and it often leads to adverse pregnancy outcomes and seriously harms the health of mothers and infants. ATP-binding cassette transporter G1 (ABCG1) plays critical roles in high-density lipoprotein (HDL) metabolism and reverse cholesterol transport. This study was designed to explore the relevance of the ABCG1 polymorphisms in the atherometabolic risk in GDM.

Study design

The case-control population consists of 1504 subjects. The rs2234715 and rs57137919 single nucleotide polymorphisms (SNPs) were genotyped using PCR and DNA sequencing, and clinical and metabolic parameters were determined.

Results

The genotype distributions of the two SNPs showed no difference between the GDM patient and control groups. However, the rs57137919 polymorphism was associated with total cholesterol (TC), and diastolic blood pressure (DBP) levels in patients with GDM. Moreover, subgroup analysis showed that this polymorphism was associated with ApoA1 and DBP levels in overweight/obese patients with GDM, while it was associated with TC, and gestational weight gain (GWG) in non-obese patients with GDM. Meanwhile, the rs2234715 polymorphism was found to be associated with neonatal birth height in non-obese patients with GDM.

Conclusions

The two polymorphisms in the ABCG1 have an influence on atherometabolic traits, GWG, and fetal growth in GDM, depending on the BMI of the patients.

中文翻译：

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妊娠期糖尿病孕妇 ATP 结合盒转运蛋白 G1 (ABCG1) 多态性

背景和目标

妊娠期糖尿病（GDM）是妊娠期最常见的代谢性疾病，常导致不良妊娠结局，严重危害母婴健康。ATP 结合盒转运蛋白 G1 (ABCG1) 在高密度脂蛋白 (HDL) 代谢和逆转胆固醇转运中发挥着关键作用。本研究旨在探讨 ABCG1 多态性与 GDM 动脉粥样代谢风险的相关性。

学习规划

病例对照人群由 1504 名受试者组成。使用 PCR 和 DNA 测序对 rs2234715 和 rs57137919 单核苷酸多态性 (SNP) 进行基因分型，并确定临床和代谢参数。

结果

两个SNP的基因型分布在GDM患者和对照组之间没有显示差异。然而，rs57137919 多态性与 GDM 患者的总胆固醇 (TC) 和舒张压 (DBP) 水平相关。此外，亚组分析表明，该多态性与超重/肥胖 GDM 患者的 ApoA1 和 DBP 水平相关，而与非肥胖 GDM 患者的 TC 和妊娠体重增加 (GWG) 相关。同时，发现rs2234715多态性与非肥胖GDM患者的新生儿出生身高相关。

结论

ABCG1 中的两种多态性对 GDM 中的动脉粥样代谢特征、GWG 和胎儿生长有影响，具体取决于患者的 BMI。