Dietary regulation of peroxisome proliferator-activated receptors in metabolic syndrome,Phytomedicine

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Dietary regulation of peroxisome proliferator-activated receptors in metabolic syndrome
Phytomedicine ( IF 6.7 ) Pub Date : 2023-05-29 , DOI: 10.1016/j.phymed.2023.154904
Haoyang Zou ₁ , Yiyao Gong ₁ , Haiqing Ye ₁ , Cuiping Yuan ₂ , Tiezhu Li ₂ , Jie Zhang ₁ , Li Ren ₁

Affiliation

Background

Peroxisome proliferator-activated receptors (PPARs) are a class of ligand-activated nuclear transcription factors, members of the type nuclear receptor superfamily, with three subtypes, namely PPARα, PPARβ/δ, and PPARγ, which play a key role in the metabolic syndrome. In the past decades, a large number of studies have shown that natural products can act by regulating metabolic pathways mediated by PPARs.

Purpose

This work summarizes the physiological importance and clinical significance of PPARs and reviews the experimental evidence that natural products mediate metabolic syndrome via PPARs.

Methods

This study reviews relevant literature on clinical trials, epidemiology, animals, and cell cultures published in NCBI PubMed, Scopus, Web of Science, Google Scholar, and other databases from 2001 to October 2022. Search keywords were "natural product" OR "botanical" OR "phytochemical" AND "PPAR" as well as free text words.

Results

The modulatory involvement of PPARs in the metabolic syndrome has been supported by prior research. It has been observed that many natural products can treat metabolic syndrome by altering PPARs. The majority of currently described natural compounds are mild PPAR-selective agonists with therapeutic effects that are equivalent to synthetic medicines but less harmful adverse effects.

Conclusion

PPAR agonists can be combined with natural products to treat and prevent metabolic syndrome. Further human investigations are required because it is unknown how natural products cause harm and how they might have negative impacts.

中文翻译：

代谢综合征过氧化物酶体增殖物激活受体的饮食调节

背景

过氧化物酶体增殖物激活受体（Peroxisome proliferator-activated receptors, PPARs）是一类配体激活的核转录因子，属于核受体超家族成员，具有三种亚型，即PPARα、PPARβ/δ和PPARγ，在代谢综合征中起关键作用. 在过去的几十年中，大量研究表明天然产物可以通过调节 PPARs 介导的代谢途径发挥作用。

目的

这项工作总结了 PPAR 的生理重要性和临床意义，并回顾了天然产物通过PPAR介导代谢综合征的实验证据。

方法

本研究回顾了 2001 年至 2022 年 10 月在 NCBI PubMed、Scopus、Web of Science、Google Scholar 和其他数据库中发表的有关临床试验、流行病学、动物和细胞培养的相关文献。搜索关键词是“天然产品”或“植物”或“植物化学”和“PPAR”以及自由文本词。