A newly composed single-cell transcriptomic atlas of tumor-infiltrating T cells across 16 cancer types revealed previously undescribed T cell states and heterogeneity. A unique T cell stress response state, TSTR, was linked to immunotherapy resistance. Our high-resolution T cell reference maps, web portal, and annotation tool can assist efforts to develop T cell therapies.

中文翻译：

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肿瘤浸润 T 细胞的应激反应与免疫治疗耐药性相关

新组成的 16 种癌症类型的肿瘤浸润 T 细胞的单细胞转录组图谱揭示了以前未描述的 T 细胞状态和异质性。一种独特的 T 细胞应激反应状态 TSTR 与免疫治疗耐药性相关。我们的高分辨率 T 细胞参考图、门户网站和注释工具可以帮助开发 T 细胞疗法。