A tert-butyl hydroperoxide-promoted oxidative annulation reaction of isatins with 2-(trimethylsilyl)aryl triflates for the convenient synthesis of acridone derivatives has been established. Mechanistic investigation suggested that the reaction may proceed via consecutive Baeyer–Villiger-type rearrangement followed by an intermolecular cyclization. This synthetic approach offers several advantages, including broad substrate scope, good functional group tolerance, and simplicity of operation. Additionally, successful late-stage modification of the obtained compounds was achieved, expanding the application potential of this methodology in organic synthesis.

中文翻译：

---

通过 TBHP 促进靛红与芳烃的氧化环化制备吖啶酮衍生物的无过渡金属方法

建立了叔丁基过氧化氢促进的靛红与2-(三甲基甲硅烷基)芳基三氟甲磺酸酯的氧化成环反应，以方便合成吖啶酮衍生物。机理研究表明该反应可能通过连续的Baeyer-Villiger型重排和随后的分子间环化进行。这种合成方法具有多种优点，包括广泛的底物范围、良好的官能团耐受性和操作简单。此外，还成功地对所得化合物进行了后期修饰，扩大了该方法在有机合成中的应用潜力。