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Biocompatibility of antifogging SiO-doped Diamond-Like carbon laparoscope coatings
Applied Surface Science ( IF 6.3 ) Pub Date : 2023-05-27 , DOI: 10.1016/j.apsusc.2023.157606
R L Leonard 1, 2, 3 , A B Bull 1, 2 , F Xue 3 , C P Haycook 3 , S K Gray 1, 2 , C W Bond 1, 2 , P E Bond 1, 2 , J C McDearman 1, 2 , D P Woods 1, 2 , J Mayfield 1, 2 , L R Brown 4 , T D Giorgio 3 , J A Johnson 1, 2
Affiliation  

Laparoscopes can suffer from fogging and contamination difficulties, resulting in a reduced field of view during surgery. A series of diamond-like carbon films, doped with SiO, were produced by pulsed laser deposition for evaluation as biocompatible, antifogging coatings. DLC films doped with SiO demonstrated hydrophilic properties with water contact angles under 40°. Samples subjected to plasma cleaning had improved contact angle results, with values under 5°. Doping the DLC films with SiO led to an average 40% decrease in modulus and 60% decrease in hardness. Hardness of the doped films, 12.0 – 13.2 GPa, was greater than that of the uncoated fused silica substrate, 9.2 GPa. The biocompatibility was assessed through CellTiter-Glo assays, with the films demonstrating statistically similar levels of cell viability when compared to the control media. The absence of ATP released by blood platelets in contact with the DLC coatings suggests in vivo hemocompatibility. The SiO doped films displayed improved transparency levels in comparison to undoped films, achieving up to an average of 80% transmission over the visible spectrum and an attenuation coefficient of 1.1 × 104 cm−1 at the 450 nm wavelength. The SiO doped DLC films show promise as a method of fog prevention for laparoscopes.



中文翻译:

防雾SiO掺杂类金刚石碳腹腔镜涂层的生物相容性

腹腔镜可能会遇到起雾和污染的问题,导致手术期间视野缩小。通过脉冲激光沉积制备了一系列掺杂 SiO 的类金刚石碳膜,用于评估生物相容性防雾涂层。掺杂 SiO 的 DLC 薄膜表现出亲水性能,水接触角低于 40°。经过等离子清洗的样品具有改善的接触角结果,其值低于 5°。用 SiO 掺杂 DLC 薄膜导致模量平均降低 40%,硬度平均降低 60%。掺杂薄膜的硬度为 12.0 – 13.2 GPa,大于未涂层熔融石英基底的硬度 9.2 GPa。通过 CellTiter-Glo 测定评估生物相容性,与对照培养基相比,薄膜显示出统计上相似的细胞活力水平。体内血液相容性。与未掺杂的薄膜相比,SiO掺杂的薄膜表现出更高的透明度水平,在可见光谱范围内实现了高达80%的平均透射率,并且在450 nm波长处的衰减系数为1.1 × 10 4 cm -1 SiO 掺杂 DLC 薄膜有望成为腹腔镜防雾方法。

更新日期:2023-05-27
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