Stimulator of interferon genes (STING) is a sensor of cyclic dinucleotides including cyclic GMP-AMP, which is produced by cyclic GMP-AMP synthase (cGAS) in response to cytosolic DNA. The cGAS–STING signaling pathway regulates both innate and adaptive immune responses, as well as fundamental cellular functions such as autophagy, senescence, and apoptosis. Mutations leading to constitutive activation of STING cause devastating human diseases. Thus, the cGAS–STING pathway is of great interest because of its role in diverse cellular processes and because of the potential therapeutic implications of targeting cGAS and STING. Here, we review molecular and cellular mechanisms of STING signaling, and we propose a framework for understanding the immunological and other cellular functions of STING in the context of disease.

干扰素基因刺激物 (STING) 是一种包括环 GMP-AMP 在内的环二核苷酸的传感器，环 GMP-AMP 是由环 GMP-AMP 合酶 (cGAS) 响应胞质 DNA 产生的。 cGAS-STING 信号通路调节先天性和适应性免疫反应，以及自噬、衰老和细胞凋亡等基本细胞功能。导致 STING 组成型激活的突变会导致毁灭性的人类疾病。因此，cGAS-STING 通路因其在多种细胞过程中的作用以及靶向 cGAS 和 STING 的潜在治疗意义而受到极大关注。在这里，我们回顾了 STING 信号传导的分子和细胞机制，并提出了一个框架来理解 STING 在疾病背景下的免疫学和其他细胞功能。