Bisphenol and phthalate exposure during pregnancy and the development of childhood lung function and asthma. The Generation R Study,Environmental Pollution

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Bisphenol and phthalate exposure during pregnancy and the development of childhood lung function and asthma. The Generation R Study
Environmental Pollution ( IF 7.6 ) Pub Date : 2023-05-27 , DOI: 10.1016/j.envpol.2023.121853
Tarik Karramass ₁ , Chalana Sol ₂ , Kurunthachalam Kannan ₃ , Leonardo Trasande ₄ , Vincent Jaddoe ₂ , Liesbeth Duijts ₅

Affiliation

The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Pediatrics, Division of Respiratory Medicine and Allergology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Department of Health, Wadsworth Center, New York State, United States; Department of Environmental Health Sciences, School of Public Health, State University of New York at Albany, New York, United States.
Department of Environmental Health Sciences, School of Public Health, State University of New York at Albany, New York, United States; Department of Pediatrics, New York, University School of Medicine, United States; Department of Environmental Medicine, New York University School of Medicine, United States; Department of Population Health, New York University School of Medicine, United States; New York Wagner School of Public Service, United States; New York University Global Institute of Public Health, New York, United States.
Department of Pediatrics, Division of Respiratory Medicine and Allergology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Neonatal and Pediatric Intensive Care, Division of Neonatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.

Background

Fetal exposure to bisphenols and phthalates may lead to alterations in the respiratory and immune system development in children, and to adverse respiratory health.

Aim

To study the associations of fetal bisphenols and phthalates exposure with lung function and asthma at age 13 years.

Study design and methods

This study among 1020 children was embedded in a population-based prospective cohort study. We measured maternal urine bisphenol and phthalate concentrations in the first, second and third trimester of pregnancy, and lung function by spirometry and asthma by questionnaires at age 13 years. Multivariable linear and logistic regression models were applied.

Results

Maternal urine bisphenol and phthalate concentrations averaged during pregnancy were not associated with childhood lung function or asthma. Associations of maternal urine bisphenol and phthalate concentrations in specific trimesters with respiratory outcomes showed that one interquartile range increase in the natural log-transformed maternal urine mono-isobutyl phthalate concentration in the second trimester was associated with a higher FEV₁/FVC, but not with asthma, accounting for confounders and multiple-testing correction. Although there were associations of higher second trimester bisphenol S with a lower FVC and FEV₁ in boys and girls, and of higher first trimester bisphenol S with a decreased risk of asthma in boys and an increased risk of asthma in girls, these results did not remain significant after correction for multiple testing. Results were not modified by maternal history of asthma or atopy.

Conclusions

Maternal urine bisphenol and phthalate concentrations averaged or in specific trimesters during pregnancy were not strongly associated with childhood lung function and asthma at age 13 years. BPS, as a BPA substitute, tended to be associated with impaired lung function and altered risk of asthma, partly sex-dependent, but its strength was limited by a relatively low detection rate and should be queried in contemporary cohorts.

中文翻译：

怀孕期间接触双酚和邻苯二甲酸盐以及儿童肺功能和哮喘的发展。R 世代研究

背景

胎儿接触双酚和邻苯二甲酸盐可能会导致儿童呼吸系统和免疫系统发育发生改变，并对呼吸系统健康造成不良影响。

目的

研究胎儿双酚和邻苯二甲酸盐暴露与 13 岁时肺功能和哮喘的关系。

研究设计和方法

这项针对 1020 名儿童的研究被纳入一项基于人群的前瞻性队列研究中。我们在妊娠早期、中期和晚期测量了母体尿液中双酚和邻苯二甲酸盐的浓度，并通过肺活量测定法测量了肺功能，并在 13 岁时通过问卷调查测量了哮喘。应用多变量线性和逻辑回归模型。

结果

怀孕期间母亲尿液中双酚和邻苯二甲酸盐的平均浓度与儿童肺功能或哮喘无关。特定妊娠期母尿双酚和邻苯二甲酸酯浓度与呼吸系统结局的关联表明，妊娠中期自然对数转换母尿邻苯二甲酸单异丁酯浓度增加一个四分位数与较高的 FEV1/FVC 相关，但与较高的 FEV1/FVC_无关。哮喘，解释混杂因素和多重测试校正。_{尽管妊娠中期双酚 S 较高与 FVC 和 FEV 1}较低存在关联在男孩和女孩中，以及妊娠早期双酚 S 较高，男孩哮喘风险降低，女孩哮喘风险增加，这些结果在校正多重测试后并不仍然显着。结果不受母亲哮喘或过敏史的影响。