Aims

This study aimed to assess the association of age at menarche (AAM) with multimorbidity and chronic diseases.

Methods

We used data regarding the reproductive history of 8,294 female participants of the Azar Cohort Study. A questionnaire assessed the participants’ demographic information, reproductive history, personal behaviors, smoking status, socioeconomic status, activity status, and wealth score index.

Results

Among 8,286 women included in the analysis, the AAM was < 12 years (early) in 648 (7.8%), 12–14 years (normal) in 4,911 (59.3%), and > 14 years (late) in 2,727 (32.9%) individuals. Early menarche was associated with a high risk of diabetes, obesity, and high WHR. On the other hand, late menarche was associated with higher rates of hypertension, stroke, and diabetes but a lower risk of MM, rheumatoid disease, obesity, abdominal obesity, and WHtR.

Conclusion

Changes in AAM have significant health implications. Factors predisposing individuals to early menarche and its consequences should be considered in chronic disease prevention strategies for adolescents and young adults.

中文翻译：

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初潮早与多病相关吗？阿扎尔队列研究的结果

目标

本研究旨在评估初潮年龄 (AAM) 与多种疾病和慢性病的关系。

方法

我们使用了Azar 队列研究 8,294 名女性参与者的生殖史数据。问卷评估了参与者的人口统计信息、生育史、个人行为、吸烟状况、社会经济状况、活动状况和财富评分指数。

结果

在参与分析的 8,286 名女性中，AAM 年龄 < 12 岁（早期）的有 648 名（7.8%），12-14 岁（正常）的有 4,911 名（59.3%），> 14 岁（晚期）的有 2,727 名（32.9%） ）个人。初潮过早与糖尿病、肥胖和高腰臀比的高风险相关。另一方面，初潮较晚与高血压、中风和糖尿病的发病率较高有关，但患多发性骨髓瘤、类风湿病、肥胖、腹部肥胖和 WHtR 的风险较低。

结论

AAM 的变化对健康具有重大影响。在青少年和年轻人的慢性病预防策略中应考虑导致个体初潮提前的因素及其后果。