The Construction of a Microbial Synthesis System for Rare Earth Enrichment and Material Applications,Advanced Materials

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The Construction of a Microbial Synthesis System for Rare Earth Enrichment and Material Applications
Advanced Materials ( IF 27.4 ) Pub Date : 2023-05-27 , DOI: 10.1002/adma.202303457
Huijing Cui ₁ , Xin Zhang ₁ , Jing Chen ₁ , Xining Qian ₁ , Yuewen Zhong ₁ , Chao Ma ₁ , Hongjie Zhang ₁ , Kai Liu ₁

Affiliation

Rare earth materials play an irreplaceable role in biomedical and high technology fields. However, typical mining and extraction approaches to rare earth elements (REEs) often lead to severe environmental problems and resource wastage due to the involvement of hazardous chemicals. Although biomining shows elegant alternatives, there are still grand challenges to sustainably isolate and recover REEs in nature because of insufficient metal-extracting microbes and RE-scavenging macromolecular tools. To obtain high-performance rare earth materials directly from rare earth ore, a new generation of biological synthesis strategies needs to be developed for the efficient preparation of REEs. The microbial synthesis system established here has achieved active biomanufacturing of high-purity rare earth products. Further, through employing robust affinity columns bioconjugated with structurally engineered proteins, outstanding separation of Eu/Lu and Dy/La is acquired with the purity of 99.9% (Eu), 97.1% (La), and 92.7% (Dy). More importantly, in situ one-pot synthesis of lanthanide-dependent methanol dehydrogenase is well harnessed and exclusively adsorbs La, Ce, Pr, and Nd in RE tailing for advanced biocatalysis, indicating high value-added application. Therefore, this novel biosynthetic platform provides an insightful roadmap to expand the scope of chassis engineering in terms of biofoundry and to manufacture valuable bioproducts related to REEs.

中文翻译：

稀土富集及材料应用的微生物合成体系的构建

稀土材料在生物医学和高科技领域发挥着不可替代的作用。然而，典型的稀土元素（REE）采矿和提取方法往往由于涉及危险化学品而导致严重的环境问题和资源浪费。尽管生物采矿展示了优雅的替代方案，但由于金属提取微生物和稀土清除大分子工具不足，在自然界中可持续分离和回收稀土元素仍然面临巨大挑战。为了直接从稀土矿石中获得高性能稀土材料，需要开发新一代生物合成策略来高效制备稀土元素。这里建立的微生物合成系统实现了高纯稀土产品的主动生物制造。此外，通过采用与结构工程蛋白生物共轭的坚固亲和柱，Eu/Lu 和 Dy/La 得到了出色的分离，纯度为 99.9% (Eu)、97.1% (La) 和 92.7% (Dy)。更重要的是，原位一锅合成镧系元素依赖性甲醇脱氢酶得到了很好的利用，可以专门吸附稀土尾矿中的La、Ce、Pr和Nd，用于先进的生物催化，具有高附加值的应用。因此，这种新颖的生物合成平台提供了一个富有洞察力的路线图，以扩大生物铸造方面的底盘工程范围，并制造与稀土相关的有价值的生物产品。

更新日期：2023-05-27

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