Late-Stage Photocatalytic Fluoroalkylation of Aromatic Crown Ethers in Aqueous Media,European Journal of Organic Chemistry

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Late-Stage Photocatalytic Fluoroalkylation of Aromatic Crown Ethers in Aqueous Media
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2023-05-26 , DOI: 10.1002/ejoc.202300478
Damian E. Yerien ₁ , Jessica Groppi ₂ , Al Postigo ₁ , Alberto Credi ₃ , Romina S. Conde ₁ , Massimo Baroncini ₄ , Sebastian Barata-Vallejo ₅

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A late stage photocatalytic highly chemo- and regioselective fluoroalkylation protocol for aromatic crown ethers is reported. High yields, mild conditions, aqueous solvent, easy scalability, as well as inexpensive reagents and catalyst make this one of the few practical direct functionalization methods for this important family of macrocycles. Its wide scope is further highlighted by the post synthetic modification of mechanically interlocked molecules.

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