Nanomedicine for the Detection and Treatment of Ocular Bacterial Infections,Advanced Materials

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Nanomedicine for the Detection and Treatment of Ocular Bacterial Infections
Advanced Materials ( IF 27.4 ) Pub Date : 2023-05-25 , DOI: 10.1002/adma.202302431
Xiaomin Huang _{1,

2,

3} , Luoyuan Li _{1,

2,

4} , Zhongxing Chen _{1,

2} , Haoyu Yu ₄ , Xinru You ₅ , Na Kong ₅ , Wei Tao ₅ , Xingtao Zhou _{1,

2} , Jinhai Huang _{1,

2}

Affiliation

Ocular bacterial infection is a prevalent cause of blindness worldwide, with substantial consequences for normal human life. Traditional treatments for ocular bacterial infections areless effective, necessitating the development of novel techniques to enable accurate diagnosis, precise drug delivery, and effective treatment alternatives. With the rapid advancement of nanoscience and biomedicine, increasing emphasis has been placed on multifunctional nanosystems to overcome the challenges posed by ocular bacterial infections. Given the advantages of nanotechnology in the biomedical industry, it can be utilized to diagnose ocular bacterial infections, administer medications, and treat them. In this review, the recent advancements in nanosystems for the detection and treatment of ocular bacterial infections are discussed; this includes the latest application scenarios of nanomaterials for ocular bacterial infections, in addition to the impact of their essential characteristics on bioavailability, tissue permeability, and inflammatory microenvironment. Through an in-depth investigation into the effect of sophisticated ocular barriers, antibacterial drug formulations, and ocular metabolism on drug delivery systems, this review highlights the challenges faced by ophthalmic medicine and encourages basic research and future clinical transformation based on ophthalmic antibacterial nanomedicine.

中文翻译：

用于检测和治疗眼部细菌感染的纳米医学

眼部细菌感染是世界范围内导致失明的普遍原因，对正常人类生活造成严重后果。眼部细菌感染的传统治疗方法效果不佳，需要开发新技术以实现准确诊断、精确药物输送和有效的治疗替代方案。随着纳米科学和生物医学的快速发展，人们越来越重视多功能纳米系统来克服眼部细菌感染带来的挑战。鉴于纳米技术在生物医学行业的优势，它可用于诊断眼部细菌感染、给药和治疗。在这篇综述中，讨论了用于检测和治疗眼部细菌感染的纳米系统的最新进展；这包括纳米材料在眼部细菌感染方面的最新应用场景，以及其基本特性对生物利用度、组织通透性和炎症微环境的影响。通过深入研究复杂的眼部屏障、抗菌药物制剂以及眼部代谢对药物递送系统的影响，该综述突出了眼科医学面临的挑战，并鼓励基于眼科抗菌纳米药物的基础研究和未来的临床转化。

更新日期：2023-05-25

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