Metal-Free Construction of Multisubstituted Indolizines via Intramolecular Amination of Allylic Alcohols,The Journal of Organic Chemistry

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Metal-Free Construction of Multisubstituted Indolizines via Intramolecular Amination of Allylic Alcohols
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2023-05-25 , DOI: 10.1021/acs.joc.3c00469
Xinxin Lv ₁ , Penghui Gao ₁ , Xiaowei Zhao ₂ , Zhiyong Jiang _{1,

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Affiliation

An intramolecular amination of allylic alcohols is developed as an efficient and general access to biologically important multisubstituted indolizines and their variants. Two metal-free synthetic platforms including using aqueous hydrochloric acid solution as the solvent and p-toluenesulfonic acid as the catalyst have been established, enabling the divergent synthesis of these valuable compounds in high yields.

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