Pesticide exposure and poisoning may rise the risk of mental health problems and suicidal tendencies. To explore the potential connection between chronic occupational exposure to pesticides and depression, anxiety, and suicide-related outcomes in farmers, a systematic review was performed. Systematic review protocol is available in PROSPERO registration number CRD42022316285. A total of fifty-seven studies met inclusion criteria: twenty-nine on depression or other mental disorders, twelve on suicide (two of them on both depression and suicide), and fourteen on pesticide poisoning or self-poisoning and death. Among the fifty-seven selected studies, eighteen were conducted in Asia, seventeen in North America, fourteen in South America, seven in European Union, one in Africa, and one in Australia/Oceania. Selected studies demonstrated an increased prevalence of depressive disorders in farmworkers exposed to pesticides as well as an increased self-reported prevalence of depression in this population. Moreover, previous pesticide poisoning increased the risk estimates for depression or other mental disorders as compared with chronic pesticide exposure. Severe pesticide poisoning and multiple poisoning showed increased risks of depressive symptoms compared with milder cases. In addition, financial difficulties and poor health were positively correlated with depression. Among studies on suicide, nine of them found that suicide rates increased in areas devoted to agriculture with intensive pesticide consumption. Moreover, studies demonstrate a higher suicide risk among farmers. The present review suggests more attention to the farmer's mental health and more detailed studies on occupational exposure to the mixture of these compounds.

农药接触和中毒可能会增加精神健康问题和自杀倾向的风险。为了探索长期职业接触农药与农民抑郁、焦虑和自杀相关结果之间的潜在联系，进行了一项系统评价。系统审查协议可在 PROSPERO 注册号 CRD42022316285 中获得。共有 57 项研究符合纳入标准：29 项关于抑郁症或其他精神障碍，12 项关于自杀（其中两项既关于抑郁症又关于自杀），14 项关于杀虫剂中毒或自我中毒和死亡。在选定的 57 项研究中，18 项在亚洲进行，17 项在北美，14 项在南美，7 项在欧盟，1 项在非洲，1 项在澳大利亚/大洋洲。选定的研究表明，接触杀虫剂的农场工人抑郁症的患病率增加，并且该人群自我报告的抑郁症患病率增加。此外，与长期接触农药相比，先前的农药中毒增加了抑郁症或其他精神障碍的风险估计。与较轻的病例相比，严重的农药中毒和多次中毒显示出抑郁症状的风险增加。此外，经济困难和健康状况不佳与抑郁症呈正相关。在关于自杀的研究中，有 9 项研究发现，在大量使用农药的农业地区，自杀率有所上升。此外，研究表明农民的自杀风险更高。目前的审查建议更多地关注农民'