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Lubricated Interfaces Enabling Simultaneous Pulsatile and Continuous Chemical Release Modes
Advanced Materials ( IF 27.4 ) Pub Date : 2023-05-25 , DOI: 10.1002/adma.202302264 Angana Borbora 1 , Yang Xu 2 , Souradeep Dey 3 , Xin Wang 4 , Yuxing Yao 5 , Biman B Mandal 3, 6, 7 , Xiaoguang Wang 2, 8 , Uttam Manna 1, 3, 7
Advanced Materials ( IF 27.4 ) Pub Date : 2023-05-25 , DOI: 10.1002/adma.202302264 Angana Borbora 1 , Yang Xu 2 , Souradeep Dey 3 , Xin Wang 4 , Yuxing Yao 5 , Biman B Mandal 3, 6, 7 , Xiaoguang Wang 2, 8 , Uttam Manna 1, 3, 7
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The release of chemicals following either pulsatile or continuous release modes is important for various potential applications, including programmed chemical reactions, mechanical actuation, and treatments of various diseases. However, the simultaneous application of both modes in a single material system has been challenging. Here, two chemical loading methods are reported in a liquid-crystal-infused porous surface (LCIPS) that enables both a pulsatile and continuous release of chemicals simultaneously. Specifically, chemicals loaded in the porous substrate exhibit a liquid crystal (LC) mesophase-dependent continuous release, whereas the chemicals dissolved in micrometer-sized aqueous droplets dispersed in the LC surface follow a pulsatile release activated by a phase transition. Moreover, the loading method of distinct molecules can be controlled to program their release mode. Finally, the pulsatile and continuous release of two distinct bioactive small molecules, tetracycline and dexamethasone, are demonstrated which display antibacterial and immunomodulatory activities for applications such as chronic wound healing and biomedical implant coating.
中文翻译：
润滑接口可实现同步脉冲和连续化学释放模式
以脉冲或连续释放模式释放化学物质对于各种潜在应用非常重要，包括程序化化学反应、机械驱动和各种疾病的治疗。然而，在单一材料系统中同时应用两种模式一直具有挑战性。在此，报道了液晶注入多孔表面（LCIPS）中的两种化学负载方法，该方法能够同时脉冲和连续释放化学物质。具体来说，加载在多孔基材中的化学物质表现出液晶（LC）中间相依赖的连续释放，而溶解在分散在液晶表面的微米尺寸水滴中的化学物质则遵循由相变激活的脉动释放。此外，可以控制不同分子的装载方法以编程其释放模式。最后，证明了两种不同的生物活性小分子（四环素和地塞米松）的脉冲和连续释放，它们在慢性伤口愈合和生物医学植入物涂层等应用中表现出抗菌和免疫调节活性。
更新日期：2023-05-25
中文翻译：
润滑接口可实现同步脉冲和连续化学释放模式
以脉冲或连续释放模式释放化学物质对于各种潜在应用非常重要，包括程序化化学反应、机械驱动和各种疾病的治疗。然而，在单一材料系统中同时应用两种模式一直具有挑战性。在此，报道了液晶注入多孔表面（LCIPS）中的两种化学负载方法，该方法能够同时脉冲和连续释放化学物质。具体来说，加载在多孔基材中的化学物质表现出液晶（LC）中间相依赖的连续释放，而溶解在分散在液晶表面的微米尺寸水滴中的化学物质则遵循由相变激活的脉动释放。此外，可以控制不同分子的装载方法以编程其释放模式。最后，证明了两种不同的生物活性小分子（四环素和地塞米松）的脉冲和连续释放，它们在慢性伤口愈合和生物医学植入物涂层等应用中表现出抗菌和免疫调节活性。
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