Excess mortality risk imparted by acute respiratory failure in children is unknown. We determined excess mortality risk associated with mechanically ventilated acute respiratory failure in pediatric sepsis. Novel ICD10-based algorithms were derived and validated to identify a surrogate for acute respiratory distress syndrome to calculate excess mortality risk. Algorithm-identified ARDS was identified with specificity of 96.7% (CI 93.0 − 98.9) and sensitivity of 70.5% (CI 44.0 – 89.7). Excess risk of mortality for ARDS was 24.4% (CI 22.9 – 26.2). Development of ARDS requiring mechanical ventilation imparts modest excess risk of mortality in septic children.

中文翻译：

---

儿童败血症与急性呼吸衰竭相关的超额死亡率


儿童急性呼吸衰竭造成的过度死亡风险尚不清楚。我们确定了与小儿脓毒症患者机械通气急性呼吸衰竭相关的超额死亡风险。衍生并验证了基于 ICD10 的新颖算法，以识别急性呼吸窘迫综合征的替代指标，从而计算超额死亡风险。算法识别的 ARDS 的特异性为 96.7% (CI 93.0 – 98.9)，敏感性为 70.5% (CI 44.0 – 89.7)。 ARDS 死亡的超额风险为 24.4% (CI 22.9 – 26.2)。发生需要机械通气的 ARDS 会给脓毒症儿童带来适度的额外死亡风险。