Synthesis of Pyrazoloazepines from 5-Aminopyrazoles and Study of Their Cytotoxicity in Cancer Treatment,European Journal of Organic Chemistry

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Synthesis of Pyrazoloazepines from 5-Aminopyrazoles and Study of Their Cytotoxicity in Cancer Treatment
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2023-05-24 , DOI: 10.1002/ejoc.202300410
Branislav Pavilek ₁ , Dušan Bortňák ₂ , Jakub Šofranko ₂ , Lucia Šofranková ₃ , Jana Špaldová ₃ , Katarína Elefantová ₃ , Petra Olejníková ₃ , Ivana Žídeková ₄ , Daniel Végh ₂ , Svetlana Dokupilová ₅ , Peter Mikuš ₅ , Albert Breier ₃ , Viktor Milata ₂

Affiliation

This research expands upon the synthesis of 1,6-dihydropyrazolo[3,4-b]azepines by optimization of reaction conditions for N-substituted 1,8-dihydropyrazolo[3,4-b]azepine derivatives. Structures are confirmed by 2D NMR analysis. The obtained derivatives are tested for their potential cytotoxic effect using mouse and human leukem

中文翻译：

5-氨基吡唑合成吡唑并氮杂卓及其在癌症治疗中的细胞毒性研究

本研究通过优化N-取代的1,8-二氢吡唑并[3,4- b ]氮杂卓衍生物的反应条件，扩展了1,6-二氢吡唑并[3,4- b ]氮杂卓的合成。通过 2D NMR 分析确认结构。使用小鼠和人类白血病细胞测试所获得的衍生物的潜在细胞毒性作用

更新日期：2023-05-24

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