Copper-Catalyzed Synthesis of α-Keto Amides from Sulfoxonium Ylides,The Journal of Organic Chemistry

当前位置： X-MOL 学术 › J. Org. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Copper-Catalyzed Synthesis of α-Keto Amides from Sulfoxonium Ylides
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2023-05-24 , DOI: 10.1021/acs.joc.3c00281
Xinghua Wang _{1,

2} , Yazhou Li _{1,

2} , Naixuan Zhao _{2,

3,

4} , Hong Liu _{1,

2} , Yu Zhou _{1,

2,

3,

4}

Affiliation

We here described a method to synthesize α-keto amides from simple sulfoxonium ylides and secondary amines under the catalysis of copper. This transformation involved a very simple and clean catalytic system, and the substrates could be extended to aryl, heteroaryl, and tert-butyl sulfoxonium ylides to give diversified α-keto amides with good yields. Additionally, the mechanistic studies indicated that the α-carbonyl aldehyde might be a key intermediate in the reaction system.

中文翻译：

铜催化磺叶立德合成 α-酮酰胺

我们在这里描述了一种在铜催化下由简单的亚砜叶立德和仲胺合成α-酮酰胺的方法。该转化涉及非常简单和清洁的催化体系，并且底物可以扩展到芳基、杂芳基和叔丁基亚锍叶立德，从而以良好的收率得到多样化的α-酮酰胺。此外，机理研究表明α-羰基醛可能是反应体系中的关键中间体。

更新日期：2023-05-24

点击分享查看原文

点击收藏

阅读更多本刊最新论文