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Copper-Catalyzed Synthesis of α-Keto Amides from Sulfoxonium Ylides
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2023-05-24 , DOI: 10.1021/acs.joc.3c00281
Xinghua Wang 1, 2 , Yazhou Li 1, 2 , Naixuan Zhao 2, 3, 4 , Hong Liu 1, 2 , Yu Zhou 1, 2, 3, 4
Affiliation  

We here described a method to synthesize α-keto amides from simple sulfoxonium ylides and secondary amines under the catalysis of copper. This transformation involved a very simple and clean catalytic system, and the substrates could be extended to aryl, heteroaryl, and tert-butyl sulfoxonium ylides to give diversified α-keto amides with good yields. Additionally, the mechanistic studies indicated that the α-carbonyl aldehyde might be a key intermediate in the reaction system.

中文翻译:

铜催化磺叶立德合成 α-酮酰胺

我们在这里描述了一种在铜催化下由简单的亚砜叶立德和仲胺合成α-酮酰胺的方法。该转化涉及非常简单和清洁的催化体系,并且底物可以扩展到芳基、杂芳基和丁基亚锍叶立德,从而以良好的收率得到多样化的α-酮酰胺。此外,机理研究表明α-羰基醛可能是反应体系中的关键中间体。
更新日期:2023-05-24
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