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Extremely Large 3D Cages in Metal–Organic Frameworks for Nucleic Acid Extraction
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2023-05-24 , DOI: 10.1021/jacs.3c02128 Gaoli Hu 1, 2 , Qi Liu 1 , Yi Zhou 3 , Wei Yan 4 , Yuqing Sun 1 , Shuang Peng 1 , Chengbin Zhao 1, 2 , Xiang Zhou 1 , Hexiang Deng 1, 2, 4
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2023-05-24 , DOI: 10.1021/jacs.3c02128 Gaoli Hu 1, 2 , Qi Liu 1 , Yi Zhou 3 , Wei Yan 4 , Yuqing Sun 1 , Shuang Peng 1 , Chengbin Zhao 1, 2 , Xiang Zhou 1 , Hexiang Deng 1, 2, 4
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Three-dimensional (3D) cages in the mesopore regime (2–50 nm) assembled from molecular building blocks are highly desirable in biological applications; however, their synthesis in crystalline form is quite challenging, as well as their structure characterization. Here, we report the synthesis of extremely large 3D cages in MOF crystals, with internal cage sizes of 6.9, and 8.5 nm in MOF-929; 9.3 and 11.4 nm in MOF-939, in cubic unit cells, a = 17.4 and 22.8 nm, respectively. These cages are constructed from relatively short organic linkers with the lengths of 0.85 and 1.3 nm, where the influence from molecular motion is minimized, thus favoring their crystallization. A 0.45 nm linker length elongation leads to a maximum 2.9 nm increase in cage size, giving a supreme efficiency in cage expansion. The spatial arrangements of these 3D cages were visualized by both X-ray diffraction and transmission electron microscopy. The efforts to obtain these cages in crystals pushed forward the size boundary for the construction of 3D cages from molecules and also exploited the limit of the area in space possibly supported per chemical bond, where the expansion efficiencies of the cages were found to play a critical role. These extremely large 3D cages in MOFs were useful in the complete extraction of long nucleic acid, such as total RNA and plasmid from aqueous solution.
中文翻译：
用于核酸提取的金属有机框架中的超大 3D 笼
由分子构件组装而成的介孔状态（2-50 nm）的三维（3D）笼在生物应用中非常理想；然而，它们的晶体形式的合成及其结构表征都非常具有挑战性。在这里，我们报道了 MOF 晶体中极大 3D 笼的合成，其内部笼尺寸为 6.9 nm，MOF-929 中的内部笼尺寸为 8.5 nm；MOF-939 中的 9.3 和 11.4 nm，在立方晶胞中，a分别 = 17.4 和 22.8 nm。这些笼由长度相对较短的有机连接体构成，长度为 0.85 和 1.3 nm，分子运动的影响最小化，从而有利于它们的结晶。0.45 nm 连接体长度延伸导致笼尺寸最大增加 2.9 nm，从而实现笼扩张的最高效率。这些 3D 笼的空间排列通过 X 射线衍射和透射电子显微镜进行可视化。在晶体中获得这些笼的努力推进了从分子构建 3D 笼的尺寸边界，并且还利用了每个化学键可能支撑的空间面积的限制，其中发现笼的膨胀效率发挥着关键作用。角色。
更新日期：2023-05-24
中文翻译：
用于核酸提取的金属有机框架中的超大 3D 笼
由分子构件组装而成的介孔状态（2-50 nm）的三维（3D）笼在生物应用中非常理想；然而，它们的晶体形式的合成及其结构表征都非常具有挑战性。在这里，我们报道了 MOF 晶体中极大 3D 笼的合成，其内部笼尺寸为 6.9 nm，MOF-929 中的内部笼尺寸为 8.5 nm；MOF-939 中的 9.3 和 11.4 nm，在立方晶胞中，a分别 = 17.4 和 22.8 nm。这些笼由长度相对较短的有机连接体构成，长度为 0.85 和 1.3 nm，分子运动的影响最小化，从而有利于它们的结晶。0.45 nm 连接体长度延伸导致笼尺寸最大增加 2.9 nm，从而实现笼扩张的最高效率。这些 3D 笼的空间排列通过 X 射线衍射和透射电子显微镜进行可视化。在晶体中获得这些笼的努力推进了从分子构建 3D 笼的尺寸边界，并且还利用了每个化学键可能支撑的空间面积的限制，其中发现笼的膨胀效率发挥着关键作用。角色。
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