The p-toluenesulfonyl chloride is one of the most common reagents for converting the poor leaving group (OH) into a good leaving group (OTs). Activating the hydroxyl group enables the chemists to prepare a wide range of functional groups from the hydroxyl compound. Besides, it acts as a protecting agent, chlorinating agent, dehydrating agent, arylating agent, and catalyst. This review describes the recent synthetic applications of p-toluenesulfonyl chloride and discusses the mechanism of reactions wherever applicable.

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对甲苯磺酰氯的合成应用：最新进展

对甲苯磺酰氯是将不良离去基团 (OH) 转化为良好离去基团 (OT) 的最常用试剂之一。激活羟基使化学家能够从羟基化合物中制备各种官能团。此外，它还用作保护剂、氯化剂、脱水剂、芳基化剂和催化剂。本综述描述了对甲苯磺酰氯的最新合成应用，并讨论了适用的反应机理。