Regiodivergent Synthesis of Densely Functionalized Indolizines via (2 + 2 + 1) Cycloaddition,The Journal of Organic Chemistry

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Regiodivergent Synthesis of Densely Functionalized Indolizines via (2 + 2 + 1) Cycloaddition
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2023-05-23 , DOI: 10.1021/acs.joc.3c00114
Shashikant Tiwari ₁ , Diwan S Rawat ₁

Affiliation

A novel metal and additive free, atom-economic method for the regiodivergent synthesis of crucial 6- or 8-substituted indolizine from meta-amide-substituted pyridine and alkyne via a [2 + 2 + 1] cycloaddition is developed. The reaction proceeds through the cleavage of the carbon–carbon triple bond. The synthesized product contains an important amide group that can be further functionalized to afford biologically active compounds.

中文翻译：

通过 (2 + 2 + 1) 环加成反应合成密集功能化吲嗪

开发了一种新的无金属和无添加剂的原子经济方法，用于通过[2 + 2 + 1] 环加成从间酰胺取代的吡啶和炔烃区域发散合成重要的 6- 或 8- 取代的中氮茚。反应通过碳-碳三键的断裂进行。合成的产物含有一个重要的酰胺基团，可以进一步功能化以提供具有生物活性的化合物。

更新日期：2023-05-23

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