Asymmetric Synthesis of Monofluorinated Carbocyclic Alcohols and Vicinal Difluorinated Heterocycles and Carbocycles,European Journal of Organic Chemistry

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Asymmetric Synthesis of Monofluorinated Carbocyclic Alcohols and Vicinal Difluorinated Heterocycles and Carbocycles
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2023-05-22 , DOI: 10.1002/ejoc.202300383
Lucas Bacheley ₁ , Ricardo Molina Betancourt ₂ , Rathies Ravindra ₂ , Gérard Guillamot ₃ , Phannarath Phansavath ₂ , Virginie Vidal ₄

Affiliation

A straightforward access to novel families of enantioenriched cis-monofluorinated carbocyclic alcohols has been developed through ruthenium-catalyzed asymmetric transfer hydrogenation/dynamic kinetic resolution that proceeded in high diastereo- and enantioselectivities. Valuable enantioenriched vicinal difluorinated heterocycles and carbocycles, such as trans-difluorinated indans, tetrahydronaphthalenes, tetrahydroquinolines and chromans have been synthesized as well by deoxofluorination of the corresponding cis-fluoro alcohols.

中文翻译：

一氟碳环醇和邻位二氟杂环和碳环的不对称合成

通过钌催化的不对称转移氢化/动态动力学拆分，以高非对映和对映选择性进行，开发了一种直接获得对映体富集的顺式一氟化碳环醇的新家族的方法。有价值的对映体富集的邻位二氟化杂环和碳环，例如反式二氟化茚满、四氢萘、四氢喹啉和苯并二氢吡喃也已通过相应顺式氟醇的脱氧氟化来合成。

更新日期：2023-05-22

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