The thymoproteasome is a type of proteasome expressed specifically in thymic cortical epithelial cells. Thymoproteasome affects antigen processing of major histocompatibility complex (MHC)-I-associated peptides and optimizes positive selection of CD8⁺ T cells. However, it remains unanswered whether and how thymoproteasome-dependent MHC-I-associated self-peptides contribute to positive selection of cortical thymocytes. This short piece discusses the potential mechanisms of thymoproteasome contribution to positive selection of MHC-I-restricted CD8⁺ T cells.

中文翻译：

---

胸腺蛋白酶体塑造 CD8+ T 细胞库

胸腺蛋白酶体是一种在胸腺皮质上皮细胞中特异性表达的蛋白酶体。胸腺蛋白酶体影响主要组织相容性复合物 (MHC)-I 相关肽的抗原加工，并优化 CD8 ⁺ T 细胞的阳性选择。然而，胸腺蛋白酶体依赖性 MHC-I 相关自肽是否以及如何促进皮质胸腺细胞的正选择仍然没有答案。这篇短文讨论了胸腺蛋白酶体对 MHC-I 限制性 CD8 ⁺ T 细胞的阳性选择的潜在机制。