Fluorinated Analogues to the Pentuloses of the Pentose Phosphate Pathway,European Journal of Organic Chemistry

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Fluorinated Analogues to the Pentuloses of the Pentose Phosphate Pathway
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2023-05-19 , DOI: 10.1002/ejoc.202300339
Lukas Scheibelberger _{1,

2} , Toda Stankovic ₁ , Kaja Liepert ₁ , Andreas Kienzle ₁ , Eva-Maria Patronas ₃ , Theresa Balber _{3,

4} , Markus Mitterhauser _{3,

4,

5} , Arvand Haschemi ₆ , Katharina Pallitsch ₁

Affiliation

Deoxyfluorinated analogues of rare sugars are valuable tools in mechanistic studies on the enzymes involved in their metabolism. Here we describe the first chemical synthesis of 1-deoxy-1-fluoro-d-ribulose, 3-deoxy-3-fluoro-d-ribulose and 3-deoxy-3-fluoro-d-xylulose as tools to study the non-oxidative phase of the pentose-phosphate-pathway. Additionally, three potential radiolabeling precursors for future fluorine-18 radio-fluorinations were synthesized.

中文翻译：

磷酸戊糖途径戊糖的氟化类似物

稀有糖的脱氧氟化类似物是对其代谢所涉及的酶进行机械研究的宝贵工具。在这里，我们描述了 1-脱氧-1-氟-d-核酮糖、3-脱氧-3-氟-d-核酮糖和 3-脱氧-3-氟-d-木酮糖的首次化学合成，作为研究非-脱氧-3-氟-d-木酮糖的工具。戊糖磷酸途径的氧化阶段。此外，还合成了未来氟 18 放射性氟化的三种潜在放射性标记前体。

更新日期：2023-05-19

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