Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
间质性肺异常的发生率：MESA 肺研究
European Respiratory Journal
(
IF
16.6
)
Pub Date : 2023-06-08
, DOI:
10.1183/13993003.01950-2022
Claire F McGroder
1
,
Spencer Hansen
2
,
Karen Hinckley Stukovsky
2
,
David Zhang
1
,
P Hrudaya Nath
3
,
Mary M Salvatore
4
,
Sushilkumar K Sonavane
5
,
Nina Terry
3
,
Justin T Stowell
5
,
Belinda M D'Souza
4
,
Jay S Leb
4
,
Shifali Dumeer
4
,
Muhammad U Aziz
3
,
Kiran Batra
6
,
Eric A Hoffman
7
,
Elana J Bernstein
1
,
John S Kim
1,
8
,
Anna J Podolanczuk
1,
9
,
Jerome I Rotter
10
,
Ani W Manichaikul
11,
12
,
Stephen S Rich
11,
12
,
David J Lederer
1,
13
,
R Graham Barr
1,
14
,
Robyn L McClelland
2
,
Christine Kim Garcia
15,
16,
17
Affiliation
- Department of Medicine, Columbia University Medical Center, New York, NY, USA.
- Department of Biostatistics, University of Washington, Seattle, WA, USA.
- Department of Radiology, University of Alabama, Birmingham, AL, USA.
- Department of Radiology, Columbia University Medical Center, New York, NY, USA.
- Department of Radiology, Mayo Clinic at Jacksonville, Jacksonville, FL, USA.
- University of Texas Southwestern Medical Center, Dallas, TX, USA.
- Department of Radiology, University of Iowa, Iowa City, IA, USA.
- Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA.
- Department of Medicine, Weill Medical College of Cornell University, New York, NY, USA.
- The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
- Department of Public Health Sciences, University of Virginia, Charlotte, VA, USA.
- Center for Public Health Genomics, University of Virginia, Charlotte, VA, USA.
- Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA.
- Department of Epidemiology, Columbia University Medical Center, New York, NY, USA.
- Department of Medicine, Columbia University Medical Center, New York, NY, USA
- Institute for Genomic Medicine, Columbia University Medical Center, New York, NY, USA.
- Center for Precision Medicine and Genomics, Columbia University Medical Center, New York, NY, USA.
背景
新发生的间质性肺异常 (ILA) 和纤维化 ILA 的发生率此前尚未有报道。
方法
训练有素的胸部放射科医生评估了 2000 年至 2012 年间 6197 名年龄 > 45 岁的动脉粥样硬化多种族研究 (MESA) 纵向队列研究参与者的 13 944 次心脏计算机断层扫描是否存在 ILA。其中 5% 的扫描结果由相同或不同的观察者以盲目的方式。排除基线时患有 ILA 的参与者后，计算 ILA 和纤维化 ILA 的发病率和发病率比。
结果
ILA 的读者内一致性为 92.0%（Gwet 的 AC1 0.912，组内相关系数（ICC）0.982），ILA 的读者间一致性为 83.5%（Gwet 的 AC1 0.814，ICC 0.969）。 ILA 和纤维化 ILA 的发病率估计分别为每 1000 人年 13.1 例和 3.5 例。在多变量分析中，年龄（风险比 (HR) 1.06 (95% CI 1.05–1.08)；p<0 id=6>MUC5B 启动子单核苷酸多态性 (HR 1.73 (95% CI 1.17–2.56)；p=0.01 和 HR 4.96 (95% CI 2.68–9.15)；p<0.001) 分别与偶发性 ILA 和纤维化 ILA 相关 (HR 2.31 (95% CI 1.34–3.96)；p=0.002) 和特发性肺纤维化多基因相关。风险评分（HR 2.09（95% CI 1.61–2.71）；p<0.001）仅与纤维化 ILA 相关。
结论
事件 ILA 和纤维化 ILA 通过心脏影像学研究的回顾进行评估。这些发现可能会导致动脉粥样硬化筛查工具的更广泛应用，以识别临床前肺部疾病。
"点击查看英文标题和摘要"
Incidence of interstitial lung abnormalities: the MESA Lung Study
Background
The incidence of newly developed interstitial lung abnormalities (ILA) and fibrotic ILA has not been previously reported.
Methods
Trained thoracic radiologists evaluated 13 944 cardiac computed tomography scans for the presence of ILA in 6197 Multi-Ethnic Study of Atherosclerosis (MESA) longitudinal cohort study participants >45 years of age from 2000 to 2012. Five percent of the scans were re-read by the same or a different observer in a blinded fashion. After exclusion of participants with ILA at baseline, incidence rates and incidence rate ratios for ILA and fibrotic ILA were calculated.
Results
The intra-reader agreement of ILA was 92.0% (Gwet's AC1 0.912, intraclass correlation coefficient (ICC) 0.982) and the inter-reader agreement of ILA was 83.5% (Gwet's AC1 0.814, ICC 0.969). Incidence of ILA and fibrotic ILA was estimated to be 13.1 and 3.5 cases per 1000 person-years, respectively. In multivariable analyses, age (hazard ratio (HR) 1.06 (95% CI 1.05–1.08); p<0.001 and HR 1.08 (95% CI 1.06–1.11); p<0.001), high attenuation area at baseline (HR 1.05 (95% CI 1.03–1.07); p<0.001 and HR 1.06 (95% CI 1.02–1.10); p=0.002) and the MUC5B promoter single nucleotide polymorphism (HR 1.73 (95% CI 1.17–2.56); p=0.01 and HR 4.96 (95% CI 2.68–9.15); p<0.001) were associated with incident ILA and fibrotic ILA, respectively. Ever-smoking (HR 2.31 (95% CI 1.34–3.96); p=0.002) and an idiopathic pulmonary fibrosis polygenic risk score (HR 2.09 (95% CI 1.61–2.71); p<0.001) were associated only with incident fibrotic ILA.
Conclusions
Incident ILA and fibrotic ILA were estimated by review of cardiac imaging studies. These findings may lead to wider application of a screening tool for atherosclerosis to identify pre-clinical lung disease.
更新日期：2023-06-08
京公网安备 11010802027423号