The pharmacology and mechanisms of traditional Chinese medicine in promoting liver regeneration: A new therapeutic option,Phytomedicine

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The pharmacology and mechanisms of traditional Chinese medicine in promoting liver regeneration: A new therapeutic option
Phytomedicine ( IF 6.7 ) Pub Date : 2023-05-18 , DOI: 10.1016/j.phymed.2023.154893
Jia-Ting Ma ₁ , Shuang Xia ₁ , Bi-Kui Zhang ₁ , Fen Luo ₁ , Lin Guo ₁ , Yan Yang ₁ , Hui Gong ₁ , Miao Yan ₁

Affiliation

Background

The liver is renowned for its remarkable regenerative capacity to restore its structure, size and function after various types of liver injury. However, in patients with end-stage liver disease, the regenerative capacity is inhibited and liver transplantation is the only option. Considering the limitations of liver transplantation, promoting liver regeneration is suggested as a new therapeutic strategy for liver disease. Traditional Chinese medicine (TCM) has a long history of preventing and treating various liver diseases, and some of them have been proven to be effective in promoting liver regeneration, suggesting the therapeutic potential in liver diseases.

Purpose

This review aims to summarize the molecular mechanisms of liver regeneration and the pro-regenerative activity and mechanism of TCM formulas, extracts and active ingredients.

Methods

We conducted a systematic search in PubMed, Web of Science and the Cochrane Library databases using "TCM", "liver regeneration" or their synonyms as keywords, and classified and summarized the retrieved literature. The PRISMA guidelines were followed.

Results

Forty-one research articles met the themes of this review and previous critical studies were also reviewed to provide essential background information. Current evidences indicate that various TCM formulas, extracts and active ingredients have the effect on stimulating liver regeneration through modulating JAK/STAT, Hippo, PI3K/Akt and other signaling pathways. Besides, the mechanisms of liver regeneration, the limitation of existing studies and the application prospect of TCM to promote liver regeneration are also outlined and discussed in this review.

Conclusion

This review supports TCM as new potential therapeutic options for promoting liver regeneration and repair of the failing liver, although extensive pharmacokinetic and toxicological studies, as well as elaborate clinical trials, are still needed to demonstrate safety and efficacy.

中文翻译：

中药促进肝再生的药理与机制：一种新的治疗选择

背景

肝脏以其非凡的再生能力而闻名，可以在各种类型的肝损伤后恢复其结构、大小和功能。然而，对于终末期肝病患者，再生能力受到抑制，肝移植是唯一的选择。考虑到肝移植的局限性，促进肝再生被认为是一种新的肝病治疗策略。中医防治多种肝病历史悠久，部分中医已被证明具有促进肝再生的作用，显示出治疗肝病的潜力。

目的

本综述旨在总结肝再生的分子机制以及中药方剂、提取物和活性成分的促再生活性和机制。

方法

我们以“TCM”、“肝再生”或其近义词为关键词，在PubMed、Web of Science和Cochrane Library数据库中进行了系统检索，并对检索到的文献进行了归类和归纳。遵循了 PRISMA 准则。

结果

四十一篇研究文章符合本次审查的主题，并且还审查了以前的批判性研究以提供必要的背景信息。目前的证据表明，各种中药方剂、提取物和活性成分通过调节JAK/STAT、Hippo、PI3K/Akt等信号通路，具有促进肝再生的作用。此外，本综述还概述和讨论了肝再生的机制、现有研究的局限性以及中医药促进肝再生的应用前景。