当前位置：
X-MOL 学术
›
J. Cell Biol.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Not just protons: Chloride also activates lysosomal acidic hydrolases
Journal of Cell Biology ( IF 7.4 ) Pub Date : 2023-05-16 , DOI: 10.1083/jcb.202305007 Xinghua Feng 1, 2 , Siyu Liu 2, 3 , Haoxing Xu 1, 2, 4
Journal of Cell Biology ( IF 7.4 ) Pub Date : 2023-05-16 , DOI: 10.1083/jcb.202305007 Xinghua Feng 1, 2 , Siyu Liu 2, 3 , Haoxing Xu 1, 2, 4
Affiliation
Lysosomal hydrolases require an acidic lumen for their optimal activities. In this issue, two independent groups (Wu et al. 2023. J. Cell Biol.https://doi.org/10.1083/jcb.202208155; Zhang et al. 2023. J. Cell. Biol.https://doi.org/10.1083/jcb.202210063) report that hydrolase activation also requires high intralysosomal Cl−, which is established by the lysosomal Cl−/H+ exchanger ClC-7.
中文翻译：
不仅仅是质子：氯化物还能激活溶酶体酸性水解酶
溶酶体水解酶需要酸性腔才能发挥最佳活性。本期，两个独立小组（Wu et al. 2023. J. Cell Biol.https://doi.org/10.1083/jcb.202208155；Zhang et al. 2023. J. Cell. Biol.https://doi .org/10.1083/jcb.202210063）报告称，水解酶的激活也需要高溶酶体内 Cl−，这是由溶酶体 Cl−/H+ 交换剂 ClC-7 建立的。
更新日期：2023-05-16
中文翻译：
不仅仅是质子：氯化物还能激活溶酶体酸性水解酶
溶酶体水解酶需要酸性腔才能发挥最佳活性。本期，两个独立小组（Wu et al. 2023. J. Cell Biol.https://doi.org/10.1083/jcb.202208155；Zhang et al. 2023. J. Cell. Biol.https://doi .org/10.1083/jcb.202210063）报告称，水解酶的激活也需要高溶酶体内 Cl−，这是由溶酶体 Cl−/H+ 交换剂 ClC-7 建立的。
京公网安备 11010802027423号