Wound closure is critical for the care of wounds by preventing foreign matter entry and supporting healing. Failure of wound closure because of mechanical compromise or inflammation can lead to failure of effective apposition of tissues and manifest in delayed healing and even death, depending on the site of the wound. Therefore, a platform capable of identifying inflammation as well as delivery of therapeutics, including chemical, biological, and cellular therapies, could transform our capacity to effectively sense potential failure as well as maximize healing. Here, we report the development of a decellularized gut suture platform capable of sensing inflammation as well as delivering a broad array of therapeutics, including small molecules, monoclonal antibodies, and cell-based therapeutics. We demonstrate the mechanical and biological functionalities of our platform in rodents and pigs. We anticipate that this platform could transform how we care for wounds and anastomoses of patients.

伤口闭合可防止异物进入并支持愈合，对于伤口护理至关重要。由于机械损伤或炎症而导致的伤口闭合失败可能导致组织无法有效贴合，并表现为愈合延迟甚至死亡，具体取决于伤口的部位。因此，一个能够识别炎症以及提供治疗（包括化学、生物和细胞疗法）的平台可以改变我们有效感知潜在失败以及最大限度地治愈的能力。在这里，我们报告了一种脱细胞肠道缝合平台的开发，该平台能够感知炎症并提供广泛的治疗药物，包括小分子、单克隆抗体和基于细胞的治疗药物。我们在啮齿动物和猪身上展示了我们平台的机械和生物功能。我们预计这个平台可以改变我们护理患者伤口和吻合的方式。