Neuroendocrine neoplasms represent an uncommon disease with an increasing incidence. Thanks to improvements in diagnostic and therapeutic methods, metastases previously considered uncommon, such as bone metastases, or even very rare, such as brain, orbital and cardiac metastases, are more frequently found in daily practice. Due to the great heterogeneity of these neoplasms, there is a lack of high-quality evidence on the management of patients with these types of metastases. The aim of this review is to provide the current state of the art, reviewing neuroendocrine neoplasm specific studies and useful information from other tumor types and to propose a treatment recommendation with algorithms to consider in daily clinical practice.

神经内分泌肿瘤是一种发病率不断增加的罕见疾病。由于诊断和治疗方法的改进，以前被认为不常见的转移，例如骨转移，甚至非常罕见的转移，例如脑、眼眶和心脏转移，在日常实践中更常见。由于这些肿瘤的巨大异质性，缺乏关于此类转移患者治疗的高质量证据。本综述的目的是提供当前的最新技术，回顾神经内分泌肿瘤的具体研究和其他肿瘤类型的有用信息，并提出治疗建议和日常临床实践中考虑的算法。